MAGEA2
| Gene Symbol | MAGEA2 |
|---|---|
| Entrez Gene | 4101 |
| Alt Symbol | CT1.2, MAGE2, MAGEA2A |
| Species | Human |
| Gene Type | protein-coding |
| Description | melanoma antigen family A2 |
| Other Description | MAGE-2 antigen|cancer/testis antigen 1.2|cancer/testis antigen family 1, member 2|melanoma antigen 2|melanoma antigen family A, 2|melanoma-associated antigen 2 |
| Swissprots | Q32NC6 A8K328 P43356 |
| Accessions | AAA17729 EAW99429 EAW99430 EAW99431 P43356 AK290443 BAF83132 AU100045 BC013098 AAH13098 BC063681 AAH63681 BC108720 AAI08721 BC109188 AAI09189 BC112158 AAI12159 BC112160 AAI12161 BC146449 AAI46450 BG575302 BM781931 BX282627 CA429655 DR158683 XM_011531159 XP_011529461 NM_001282501 NP_001269430 NM_001282502 NP_001269431 NM_001282504 NP_001269433 NM_001282505 NP_001269434 NM_005361 NP_005352 NM_175742 NP_786884 NM_175743 NP_786885 |
| Function | Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}. |
| Subcellular Location | Nucleus. Nucleus, PML body. |
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
MAGE-A2 CRISPR/Cas9 KO Plasmid (h) - sc-417373 from Santa Cruz Biotechnology
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MAGE-A2 HDR Plasmid (h) - sc-417373-HDR from Santa Cruz Biotechnology
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MAGE-A2 Double Nickase Plasmid (h) - sc-417373-NIC from Santa Cruz Biotechnology
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MAGE-A2 Double Nickase Plasmid (h2) - sc-417373-NIC-2 from Santa Cruz Biotechnology
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MAGE-A2 CRISPR Activation Plasmid (h) - sc-417373-ACT from Santa Cruz Biotechnology
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MAGE-A2 CRISPR Activation Plasmid (h2) - sc-417373-ACT-2 from Santa Cruz Biotechnology
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MAGE-A2 Lentiviral Activation Particles (h) - sc-417373-LAC from Santa Cruz Biotechnology
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MAGE-A2 Lentiviral Activation Particles (h2) - sc-417373-LAC-2 from Santa Cruz Biotechnology
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MAGE-A2 siRNA (h) - sc-108018 from Santa Cruz Biotechnology
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MAGE-A2 shRNA Plasmid (h) - sc-108018-SH from Santa Cruz Biotechnology
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MAGE-A2 shRNA (h) Lentiviral Particles - sc-108018-V from Santa Cruz Biotechnology
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MAGEA2 RNAi - H00004101-R03 from Novus Biologicals
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MISSION® 3′UTR Lenti GoClone™ - HUTR04624 from Sigma-Aldrich
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MAGEA2 siRNA (Human) - CRH2781 from Cohesion Biosciences
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MAGEA2 RNAi - H00004101-R02 from Novus Biologicals
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MAGEA2 RNAi - H00004101-R01 from Novus Biologicals
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shRNA set against Human Magea2 (NM_175743.1) - SHH336735 from Creative biogene
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Human MAGEA2B siRNA - orb277334 from Biorbyt
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Human MAGEA2 siRNA - orb263283 from Biorbyt
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MAGEA2 shRNA Plasmid (Human) - CHH2781 from Cohesion Biosciences
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MAGEA2 miRNA 3'UTR clone - MiUTR4H-TG05274 from Creative biogene
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