MAGEA2

Gene Symbol	MAGEA2
Entrez Gene	4101
Alt Symbol	CT1.2, MAGE2, MAGEA2A
Species	Human
Gene Type	protein-coding
Description	melanoma antigen family A2
Other Description	MAGE-2 antigen|cancer/testis antigen 1.2|cancer/testis antigen family 1, member 2|melanoma antigen 2|melanoma antigen family A, 2|melanoma-associated antigen 2
Swissprots	Q32NC6 A8K328 P43356
Accessions	AAA17729 EAW99429 EAW99430 EAW99431 P43356 AK290443 BAF83132 AU100045 BC013098 AAH13098 BC063681 AAH63681 BC108720 AAI08721 BC109188 AAI09189 BC112158 AAI12159 BC112160 AAI12161 BC146449 AAI46450 BG575302 BM781931 BX282627 CA429655 DR158683 XM_011531159 XP_011529461 NM_001282501 NP_001269430 NM_001282502 NP_001269431 NM_001282504 NP_001269433 NM_001282505 NP_001269434 NM_005361 NP_005352 NM_175742 NP_786884 NM_175743 NP_786885
Function	Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}.
Subcellular Location	Nucleus. Nucleus, PML body.
Tissue Specificity	Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAGEA2 full length protein - ab158844 from Abcam Category Protein Source Wheat germ Species Human

Human MAGEA2 full length protein - ab166101 from Abcam Category Protein Source Wheat germ Species Human

MAGEA2 Antibody Blocking Peptide - LS-E8104 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAGEA2 Antibody Blocking Peptide - LS-E21923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MAGEA2 Protein - H00004101-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAGEA2 Peptide - P1772 from Novus Biologicals Category Peptide Species Human

MAGEA2-Antibody-N-term-Blocking-Peptide - BP6164a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAGE-A2-157-166 - SP2473b from Abgent, a WuXi AppTec company Category Peptide Prices $205.00 Sizes 5 mg

MAGE-A2-157-166 - SP2473a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg

MAGEA2 Blocking Peptide - 33R-4987 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAGE-2 - H00004101-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAGE-2 - H00004101-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAGEA2 fusion protein - Ag6090 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MAGEA2 fusion protein - Ag5889 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MAGEA2 fusion protein - ag3141 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MAGEA2, His-tagged - MAGEA2-691H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Melanoma-associated antigen 2(MAGEA2) - CSB-YP013327HU CSB-EP013327HU CSB-BP013327HU CSB-MP013327HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAGEA2 Peptide - abx164621 from Abbexa Category Peptide Species Human

MAGEA2 Peptide, Human - M34GP09083H from Creative Peptides Category Peptide Source Synthetic. Species Human

MAGE-2 (157-166) - ta-450 from Creative Peptides Category Peptide Source Homo sapiens (human)

MAGE-2 (156-164) - ta-451 from Creative Peptides Category Peptide Source Homo sapiens (human)

MAGE-2 (127-136) - ta-452 from Creative Peptides Category Peptide Source Homo sapiens (human)

MAGE-2 (212-220) - ta-453 from Creative Peptides Category Peptide Source Homo sapiens (human)

Melanoma-associated antigen 2 (MAGEA2), Recombinant Protein - MBS951470 from MyBioSource Category Protein Prices $1,075.00, $1,075.00, $1,305.00, $1,305.00, $1,680.00, $1,680.00, $2,145.00, $2,145.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more