| Gene Symbol |
MAGEA2
|
| Entrez Gene |
4101
|
| Alt Symbol |
CT1.2, MAGE2, MAGEA2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
melanoma antigen family A2
|
| Other Description |
MAGE-2 antigen|cancer/testis antigen 1.2|cancer/testis antigen family 1, member 2|melanoma antigen 2|melanoma antigen family A, 2|melanoma-associated antigen 2
|
| Swissprots |
Q32NC6 A8K328 P43356
|
| Accessions |
AAA17729 EAW99429 EAW99430 EAW99431 P43356 AK290443 BAF83132 AU100045 BC013098 AAH13098 BC063681 AAH63681 BC108720 AAI08721 BC109188 AAI09189 BC112158 AAI12159 BC112160 AAI12161 BC146449 AAI46450 BG575302 BM781931 BX282627 CA429655 DR158683 XM_011531159 XP_011529461 NM_001282501 NP_001269430 NM_001282502 NP_001269431 NM_001282504 NP_001269433 NM_001282505 NP_001269434 NM_005361 NP_005352 NM_175742 NP_786884 NM_175743 NP_786885
|
| Function |
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}.
|
| Subcellular Location |
Nucleus. Nucleus, PML body.
|
| Tissue Specificity |
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
|