SYK

Gene Symbol	SYK
Entrez Gene	6850
Alt Symbol	p72-Syk
Species	Human
Gene Type	protein-coding
Description	spleen tyrosine kinase
Other Description	tyrosine-protein kinase SYK
Swissprots	P43405
Accessions	EAW62782 EAW62783 EAW62784 EAW62785 EAW62786 P43405 AJ420449 AK057772 AK075020 BAG52053 AK094808 AK290927 BAF83616 AL832053 BC001645 AAH01645 BC002962 AAH02962 BC011399 AAH11399 BG754228 BM019270 BU429809 BX647192 DA587403 DA948098 DB458719 FN391891 CAY55929 FN391892 CAY55930 FN391893 CAY55931 L28824 AAA36526 S80267 AAB35601 W33104 X73568 CAA51970 Z29630 CAA82737 XM_005252147 XP_005252204 XM_011518946 XP_011517248 XM_011518947 XP_011517249 XR_929837 NM_001135052 NP_001128524 NM_001174167 NP_001167638 NM_001174168 NP_001167639 NM_003177 NP_003168
Function	Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR
Subcellular Location	Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}.
Tissue Specificity	Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells. {ECO:0000269|PubMed:8163536}.
Top Pathways	Tuberculosis, Epstein-Barr virus infection, PI3K-Akt signaling pathway, Viral carcinogenesis, Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Syk gene - orb91119 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-SYK-cDNA-Clone - DC01193 from Abgent, a WuXi AppTec company Prices $857.25 Sizes 10 µg Species Human Accession BC002962

SYK - MBS1273382 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC002962

SYK - MBS1275545 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011399

Human SYK cDNA clone(NM_001174167.1) - CDFH019053 from Creative Biomart Species Human Accession NM_001174167.1

Human SYK cDNA clone(NM_001174168.1) - CDFH019054 from Creative Biomart Species Human Accession NM_001174168.1

Human Syk ORF clone(NM_003177.5) - CDCL186366 from Creative Biomart Species Human Accession NM_003177.5

human SYK ORF clone - CDCH087886 from Creative Biomart Species Human Accession NM_001135052

human SYK ORF clone - CDCH087887 from Creative Biomart Species Human Accession NM_001135052

human SYK ORF clone - CDCH087888 from Creative Biomart Species Human Accession NM_001135052

human SYK ORF clone - CDCH087889 from Creative Biomart Species Human Accession NM_001135052

Human SYK ORF Clone(NM_003177.5) - CDCL177623 from Creative Biomart Species Human Accession NM_003177.5

Human SYK ORF Clone(NM_001135052.2) - CDCL177624 from Creative Biomart Species Human Accession NM_001135052.2

Human SYK ORF Clone(NM_001174167.1) - CDCR356986 from Creative Biomart Species Human Accession NM_001174167.1

Human SYK ORF Clone(NM_001174168.1) - CDCR356987 from Creative Biomart Species Human Accession NM_001174168.1

Human SYK ORF Clone(NM_001174168.1) - CDCR356988 from Creative Biomart Species Human Accession NM_001174168.1

Human SYK ORF Clone(NM_001174167.1) - CDCR356992 from Creative Biomart Species Human Accession NM_001174167.1

Human Syk transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10540-M from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10540-ACR from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10540-UT from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10540-NH from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10540-NF from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10540-NM from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10540-CY from Sino Biological Species Human

Human Syk transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10540-CF from Sino Biological Species Human

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