SYK
| Gene Symbol | SYK |
|---|---|
| Entrez Gene | 6850 |
| Alt Symbol | p72-Syk |
| Species | Human |
| Gene Type | protein-coding |
| Description | spleen tyrosine kinase |
| Other Description | tyrosine-protein kinase SYK |
| Swissprots | P43405 |
| Accessions | EAW62782 EAW62783 EAW62784 EAW62785 EAW62786 P43405 AJ420449 AK057772 AK075020 BAG52053 AK094808 AK290927 BAF83616 AL832053 BC001645 AAH01645 BC002962 AAH02962 BC011399 AAH11399 BG754228 BM019270 BU429809 BX647192 DA587403 DA948098 DB458719 FN391891 CAY55929 FN391892 CAY55930 FN391893 CAY55931 L28824 AAA36526 S80267 AAB35601 W33104 X73568 CAA51970 Z29630 CAA82737 XM_005252147 XP_005252204 XM_011518946 XP_011517248 XM_011518947 XP_011517249 XR_929837 NM_001135052 NP_001128524 NM_001174167 NP_001167638 NM_001174168 NP_001167639 NM_003177 NP_003168 |
| Function | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR |
| Subcellular Location | Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}. |
| Tissue Specificity | Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells. {ECO:0000269|PubMed:8163536}. |
| Top Pathways | Tuberculosis, Epstein-Barr virus infection, PI3K-Akt signaling pathway, Viral carcinogenesis, Natural killer cell mediated cytotoxicity |
Syk CRISPR/Cas9 KO Plasmid (h) - sc-400189 from Santa Cruz Biotechnology
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Syk HDR Plasmid (h) - sc-400189-HDR from Santa Cruz Biotechnology
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Syk Double Nickase Plasmid (h) - sc-400189-NIC from Santa Cruz Biotechnology
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Syk Double Nickase Plasmid (h2) - sc-400189-NIC-2 from Santa Cruz Biotechnology
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Syk CRISPR Activation Plasmid (h) - sc-400189-ACT from Santa Cruz Biotechnology
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Syk CRISPR Activation Plasmid (h2) - sc-400189-ACT-2 from Santa Cruz Biotechnology
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Syk Lentiviral Activation Particles (h) - sc-400189-LAC from Santa Cruz Biotechnology
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Syk Lentiviral Activation Particles (h2) - sc-400189-LAC-2 from Santa Cruz Biotechnology
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Syk siRNA (h) - sc-29501 from Santa Cruz Biotechnology
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Syk shRNA Plasmid (h) - sc-29501-SH from Santa Cruz Biotechnology
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Syk shRNA (h) Lentiviral Particles - sc-29501-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU081641 from Sigma-Aldrich
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MISSION® siRNA - SIHK2216 from Sigma-Aldrich
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MISSION® siRNA - SIHK2217 from Sigma-Aldrich
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MISSION® siRNA - SIHK2218 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1072 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1313 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1072 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12172 from Sigma-Aldrich
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SYK siRNA (Human) - CRH4684 from Cohesion Biosciences
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SYK RNAi - H00006850-R02 from Novus Biologicals
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SYK - MBS8204485 from MyBioSource
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shRNA set against Human SYK (NM_003177.5) - SHH421580 from Creative biogene
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Human SYK siRNA - orb265186 from Biorbyt
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SYK shRNA Plasmid (Human) - CHH4684 from Cohesion Biosciences
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