SYK

Gene Symbol	SYK
Entrez Gene	6850
Alt Symbol	p72-Syk
Species	Human
Gene Type	protein-coding
Description	spleen tyrosine kinase
Other Description	tyrosine-protein kinase SYK
Swissprots	P43405
Accessions	EAW62782 EAW62783 EAW62784 EAW62785 EAW62786 P43405 AJ420449 AK057772 AK075020 BAG52053 AK094808 AK290927 BAF83616 AL832053 BC001645 AAH01645 BC002962 AAH02962 BC011399 AAH11399 BG754228 BM019270 BU429809 BX647192 DA587403 DA948098 DB458719 FN391891 CAY55929 FN391892 CAY55930 FN391893 CAY55931 L28824 AAA36526 S80267 AAB35601 W33104 X73568 CAA51970 Z29630 CAA82737 XM_005252147 XP_005252204 XM_011518946 XP_011517248 XM_011518947 XP_011517249 XR_929837 NM_001135052 NP_001128524 NM_001174167 NP_001167638 NM_001174168 NP_001167639 NM_003177 NP_003168
Function	Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR
Subcellular Location	Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}.
Tissue Specificity	Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells. {ECO:0000269|PubMed:8163536}.
Top Pathways	Tuberculosis, Epstein-Barr virus infection, PI3K-Akt signaling pathway, Viral carcinogenesis, Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Syk full length protein - ab60886 from Abcam Category Protein Prices $286.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human Syk protein fragment - ab196062 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Syk full length protein - ab152718 from Abcam Category Protein Source Wheat germ Species Human

Human Syk peptide - ab104947 from Abcam Category Peptide

Human Syk protein fragment - ab152719 from Abcam Category Protein Source Wheat germ Species Human

Syk peptide - ab192554 from Abcam Category Peptide

Syk peptide (458-470) - ab45752 from Abcam Category Peptide Species Human

SYK Antibody Blocking Peptide - LS-E1923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYK Antibody Blocking Peptide - LS-E3951 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYK Antibody Blocking Peptide - LS-E22338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYK Antibody Blocking Peptide - LS-E25901 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYK Recombinant Protein - H00006850-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SYK Partial Recombinant Protein - H00006850-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SYK Recombinant Protein - P3925 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Recombinant Human SYK Protein - P4780 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

SYK Peptide - P2764 from Novus Biologicals Category Peptide Species Human

SYK-Antibody-Blocking-peptide - BP12763a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYK-Antibody-C-term-S295-Blocking-peptide - BP12912b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYK-Antibody-C-term-Blocking-Peptide - BP7720b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Syk blocking peptide - GTX89525-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Recombinant Human Active SYK, CF - 4594-KS-010 from R&D Systems Category Protein

Human SYK protein - orb169383 from Biorbyt Category Protein Prices $170.00, $289.00, $961.00 Sizes 2 μg, 10 μg, 100 μg Species Human

Human Spleen Tyrosine Kinase Protein - abx069146 from Abbexa Category Protein Source E.coli Species Human

SYK (phospho-Tyr323) Blocking Peptide - abx063321 from Abbexa Category Peptide Species Human, Mouse, Rat

SYK (phospho-Tyr348) Blocking Peptide - abx063322 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit

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