MAML2

Gene Symbol	MAML2
Entrez Gene	84441
Alt Symbol	MAM-3, MAM2, MAM3, MLL-MAML2
Species	Human
Gene Type	protein-coding
Description	mastermind-like 2 (Drosophila)
Other Description	mam-2\|mastermind-like protein 2
Swissprots	Q8IZL2 Q96JK6 Q6AI23 A7MD26
Accessions	EAW66975 Q8IZL2 AB058722 BAB47448 AK308157 AW513171 AY040322 AAK93831 BC143529 AAI43530 BC152449 AAI52450 CR627398 CAH10491 DA862475 XM_011543023 XP_011541325 XM_011543024 XP_011541326 XM_011543025 XP_011541327 NM_032427 NP_115803
Function	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269\|PubMed:12370315, ECO:0000269\|PubMed:12386158, ECO:0000269\|PubMed:12539049}.
Subcellular Location	Nucleus speckle {ECO:0000269\|PubMed:12370315}. Note=Nuclear, in a punctate manner.
Tissue Specificity	Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. {ECO:0000269\|PubMed:14720503}.
Top Pathways	Notch signaling pathway

MAML2 Antibody - 4618 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of total cell lysates from 293, NIH/3T3 and A10 cells, using MAML2 antibody.

MAML2 (D41E6) Rabbit mAb - 6988 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D41E6

Western blot analysis of extracts from 293 and SH-SY5Y cells using MAML2 (D41E6) Rabbit mAb.

MAML2 (N-15) - sc-82217 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MAML2 (H-240) - sc-68907 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

MAML2 (G-07) - sc-100778 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

MAML2 (G-07): sc-100778. Western blot analysis of MAML2 expression in MCF7 whole cell lysate.

Anti-MAML2 antibody - ab65091 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab65091 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal Goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab65091, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 Goat anti-Rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 4% PFA fixed (10 min) Hek293, HepG2, MCF-7 cells at 1µg/ml.

Anti-MAML2 antibody - ab90592 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab90592, at 1/250 dilution, staining MAML2 in formalin-fixed, paraffin-embedded Human stomach carcinoma by Immunohistochemistry, using DAB detection.

Anti-MAML2 antibody - ab57824 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-MAML2 Antibody (C-Terminus) - LS-C72046 from LifeSpan Bioscience

Prices	$545.00
Sizes	20 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MAML2 Antibody (aa250-300) - LS-C287551 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAML2 Antibody (aa796-895) - LS-C308866 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-MAML2 Antibody (aa796-895, Azide-free) - LS-C330524 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-MAML2 Antibody (aa324-373) - LS-C170175 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MAML2 Antibody (aa169-218) - LS-C116146 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MAML2 antibody LS-C116146 Western blot of Mouse Kidney lysate.

Anti-MAML2 Antibody (C-Terminus) - LS-C287552 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human MAML2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-MAML2 used at a dilution of 1:200 (1 Detection: DAB.

Anti-MAML2 Antibody (C-Terminus) - LS-C286672 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MAML2 Antibody - NB100-2127 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MAML2 Antibody - NBP1-82891 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MAML2 Antibody - 21360002 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: MAML2 Antibody [21360002] - Western Blot was performed using affinity purified SEQer MAML2 antibody, aa(705-804) antibody. The lanes contain 5-30ug of a whole cell extract. Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer MAML2 antibody, aa(705-804) antibody. Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec). The protein was detected as represented by the band shown.

MAML2 Antibody (4A1) - H00084441-M03 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4A1

Western Blot: MAML2 Antibody (4A1) [H00084441-M03] - Analysis of MAML2 expression in MCF-7 (Cat # L046V1).

MAML2 Antibody - H00084441-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

MAML2 Polyclonal Antibody - bs-12397R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MAML2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12397R-A350 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MAML2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12397R-A488 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MAML2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12397R-A555 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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