| Gene Symbol |
MAML2
|
| Entrez Gene |
84441
|
| Alt Symbol |
MAM-3, MAM2, MAM3, MLL-MAML2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mastermind-like 2 (Drosophila)
|
| Other Description |
mam-2|mastermind-like protein 2
|
| Swissprots |
Q8IZL2 Q96JK6 Q6AI23 A7MD26
|
| Accessions |
EAW66975 Q8IZL2 AB058722 BAB47448 AK308157 AW513171 AY040322 AAK93831 BC143529 AAI43530 BC152449 AAI52450 CR627398 CAH10491 DA862475 XM_011543023 XP_011541325 XM_011543024 XP_011541326 XM_011543025 XP_011541327 NM_032427 NP_115803
|
| Function |
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:12370315}. Note=Nuclear, in a punctate manner.
|
| Tissue Specificity |
Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. {ECO:0000269|PubMed:14720503}.
|
| Top Pathways |
Notch signaling pathway
|
![Western Blot: MAML2 Overexpression Lysate (Adult Normal) [NBP2-06024] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAML2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10223_MAML2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06024-img0001.jpg)