MAP3K4

Gene Symbol	MAP3K4
Entrez Gene	4216
Alt Symbol	MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 4
Other Description	MAP three kinase 1|MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|MEK kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412
Swissprots	Q92612 Q5VTT8 B9EG75 B7ZLD3 Q9H408 Q5VTT9 A6H8W0 Q9Y6R4
Accessions	EAW47586 EAW47587 Q9Y6R4 AA314177 AF002715 AAB68804 AF116604 AAF71029 AK124430 AK307866 BC136276 AAI36277 BC143735 AAI43736 BC143743 BC143750 BC146770 AAI46771 BE278366 BQ009477 D86968 BAA13204 XM_005266989 XP_005267046 NM_001291958 NP_001278887 NM_001301072 NP_001288001 NM_005922 NP_005913 NM_006724 NP_006715 NR_120425
Function	Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
Tissue Specificity	Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}.
Top Pathways	GnRH signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MEK kinase-4 (E-5) - sc-166196 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MEK kinase-4 (E-6) - sc-166197 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MEK kinase-4 (C-19) - sc-30664 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEK kinase-4 (D-20) - sc-30663 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEK kinase-4 (H-77) - sc-28770 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MEK kinase-4 (N-17) - sc-30662 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEK kinase-4 (K-7) - sc-100396 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-MAP3K4 antibody - ab55669 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAP3K4 antibody - ab198246 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 antibody - ab186125 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K4 antibody - ab110891 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K4 antibody - ab123714 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K4 antibody - C-terminal - ab174824 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097, AP) - LS-C262994 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097, Biotin) - LS-C262996 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097, APC) - LS-C262995 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097, FITC) - LS-C262997 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097, Azide-free, HRP) - LS-C262998 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1281-1330) - LS-C119358 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097, PE) - LS-C262999 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1201-1300, Azide-free) - LS-C327873 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-MAP3K4 / MEKK4 Antibody (aa1065-1097) - LS-C329827 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K4 / MEKK4 Antibody (Internal, clone EP551Y) - LS-C49658 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP551Y

Anti-MAP3K4 / MEKK4 Antibody (clone 6C6) - LS-C133319 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6C6

Anti-MAP3K4 / MEKK4 Antibody (aa1067-1097) - LS-C164134 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

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