| Gene Symbol |
MAP3K4
|
| Entrez Gene |
4216
|
| Alt Symbol |
MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 4
|
| Other Description |
MAP three kinase 1|MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|MEK kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412
|
| Swissprots |
Q92612 Q5VTT8 B9EG75 B7ZLD3 Q9H408 Q5VTT9 A6H8W0 Q9Y6R4
|
| Accessions |
EAW47586 EAW47587 Q9Y6R4 AA314177 AF002715 AAB68804 AF116604 AAF71029 AK124430 AK307866 BC136276 AAI36277 BC143735 AAI43736 BC143743 BC143750 BC146770 AAI46771 BE278366 BQ009477 D86968 BAA13204 XM_005266989 XP_005267046 NM_001291958 NP_001278887 NM_001301072 NP_001288001 NM_005922 NP_005913 NM_006724 NP_006715 NR_120425
|
| Function |
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
|
| Tissue Specificity |
Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}.
|
| Top Pathways |
GnRH signaling pathway, MAPK signaling pathway
|