MAP3K4

Gene Symbol	MAP3K4
Entrez Gene	4216
Alt Symbol	MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 4
Other Description	MAP three kinase 1|MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|MEK kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412
Swissprots	Q92612 Q5VTT8 B9EG75 B7ZLD3 Q9H408 Q5VTT9 A6H8W0 Q9Y6R4
Accessions	EAW47586 EAW47587 Q9Y6R4 AA314177 AF002715 AAB68804 AF116604 AAF71029 AK124430 AK307866 BC136276 AAI36277 BC143735 AAI43736 BC143743 BC143750 BC146770 AAI46771 BE278366 BQ009477 D86968 BAA13204 XM_005266989 XP_005267046 NM_001291958 NP_001278887 NM_001301072 NP_001288001 NM_005922 NP_005913 NM_006724 NP_006715 NR_120425
Function	Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
Tissue Specificity	Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}.
Top Pathways	GnRH signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAP3K4 protein fragment - ab158877 from Abcam Category Protein Source Wheat germ Species Human

MAP3K4 / MEKK4 Antibody Blocking Peptide - LS-E3586 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEKK4 Partial Recombinant Protein - H00004216-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MEKK4-Antibody-Center-C1081-Blocking-Peptide - BP14786c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP3K4 - H00004216-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP3K4 - H00004216-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAP3K4 - P5591 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

MAP3K4 fusion protein - ag16254 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MAP3K4 fusion protein - ag17708 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

MEKK4 Blocking Peptide - CBP4074 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Mitogen-activated protein kinase kinase kinase 4(MAP3K4) ,partial - CSB-YP013426HU CSB-EP013426HU CSB-BP013426HU CSB-MP013426HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MEKK4 Protein - NBP1-87734PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MEKK4 Blocking Peptide - abx162567 from Abbexa Category Peptide Species Human, Mouse, Rat

MAPK34-Antibody-N-term-Blocking-Peptide - BP1917a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEKK4-Antibody-C-term-Blocking-Peptide - BP7910a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP3K4 Peptide, Human - M34GP09174H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mitogen-activated protein kinase kinase kinase 4 (MAP3K4), partial, Recombinant Protein - MBS1302633 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MEKK4 peptide - orb256961 from Biorbyt Category Peptide

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