MAP3K4

Gene Symbol MAP3K4
Entrez Gene 4216
Alt Symbol MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 4
Other Description MAP three kinase 1|MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|MEK kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412
Swissprots Q92612 Q5VTT8 B9EG75 B7ZLD3 Q9H408 Q5VTT9 A6H8W0 Q9Y6R4
Accessions EAW47586 EAW47587 Q9Y6R4 AA314177 AF002715 AAB68804 AF116604 AAF71029 AK124430 AK307866 BC136276 AAI36277 BC143735 AAI43736 BC143743 BC143750 BC146770 AAI46771 BE278366 BQ009477 D86968 BAA13204 XM_005266989 XP_005267046 NM_001291958 NP_001278887 NM_001301072 NP_001288001 NM_005922 NP_005913 NM_006724 NP_006715 NR_120425
Function Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
Tissue Specificity Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}.
Top Pathways GnRH signaling pathway, MAPK signaling pathway

MEK Kinase-4 CRISPR/Cas9 KO Plasmid (h) - sc-404345 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 HDR Plasmid (h) - sc-404345-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 Double Nickase Plasmid (h) - sc-404345-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 Double Nickase Plasmid (h2) - sc-404345-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 CRISPR Activation Plasmid (h) - sc-404345-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 CRISPR Activation Plasmid (h2) - sc-404345-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 Lentiviral Activation Particles (h) - sc-404345-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK Kinase-4 Lentiviral Activation Particles (h2) - sc-404345-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-4 siRNA (h) - sc-35902 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEK kinase-4 shRNA Plasmid (h) - sc-35902-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEK kinase-4 shRNA (h) Lentiviral Particles - sc-35902-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEKK4 RNAi - H00004216-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MEKK4 RNAi - H00004216-R05 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU084481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1147 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1149 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1148 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12993 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12993 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04139 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04139

MAP3K4 siRNA (Human) - CRH2867 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Map3k4 (NM_005922.2) - SHH337711 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAP3K4(NM_006724.2) - SHH174161 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAP3K4(NM_005922.2) - SHH174197 from Creative biogene

Category siRNA
Species Reactivities Human

MAP3K4 shRNA Plasmid (Human) - CHH2867 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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