Gene Symbol | MAP3K4 |
---|---|
Entrez Gene | 4216 |
Alt Symbol | MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412 |
Species | Human |
Gene Type | protein-coding |
Description | mitogen-activated protein kinase kinase kinase 4 |
Other Description | MAP three kinase 1|MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|MEK kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412 |
Swissprots | Q92612 Q5VTT8 B9EG75 B7ZLD3 Q9H408 Q5VTT9 A6H8W0 Q9Y6R4 |
Accessions | EAW47586 EAW47587 Q9Y6R4 AA314177 AF002715 AAB68804 AF116604 AAF71029 AK124430 AK307866 BC136276 AAI36277 BC143735 AAI43736 BC143743 BC143750 BC146770 AAI46771 BE278366 BQ009477 D86968 BAA13204 XM_005266989 XP_005267046 NM_001291958 NP_001278887 NM_001301072 NP_001288001 NM_005922 NP_005913 NM_006724 NP_006715 NR_120425 |
Function | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}. |
Tissue Specificity | Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}. |
Top Pathways | GnRH signaling pathway, MAPK signaling pathway |
MEK Kinase-4 CRISPR/Cas9 KO Plasmid (h) - sc-404345 from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 HDR Plasmid (h) - sc-404345-HDR from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 Double Nickase Plasmid (h) - sc-404345-NIC from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 Double Nickase Plasmid (h2) - sc-404345-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 CRISPR Activation Plasmid (h) - sc-404345-ACT from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 CRISPR Activation Plasmid (h2) - sc-404345-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 Lentiviral Activation Particles (h) - sc-404345-LAC from Santa Cruz Biotechnology
|
||||||||
MEK Kinase-4 Lentiviral Activation Particles (h2) - sc-404345-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MEK kinase-4 siRNA (h) - sc-35902 from Santa Cruz Biotechnology
|
||||||||
MEK kinase-4 shRNA Plasmid (h) - sc-35902-SH from Santa Cruz Biotechnology
|
||||||||
MEK kinase-4 shRNA (h) Lentiviral Particles - sc-35902-V from Santa Cruz Biotechnology
|
||||||||
MEKK4 RNAi - H00004216-R06 from Novus Biologicals
|
||||||||
MEKK4 RNAi - H00004216-R05 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU084481 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK1147 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK1149 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK1148 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12993 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12993 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR04139 from Sigma-Aldrich
|
||||||||
MAP3K4 siRNA (Human) - CRH2867 from Cohesion Biosciences
|
||||||||
shRNA set against Human Map3k4 (NM_005922.2) - SHH337711 from Creative biogene
|
||||||||
shRNA set against Human MAP3K4(NM_006724.2) - SHH174161 from Creative biogene
|
||||||||
shRNA set against Human MAP3K4(NM_005922.2) - SHH174197 from Creative biogene
|
||||||||
MAP3K4 shRNA Plasmid (Human) - CHH2867 from Cohesion Biosciences
|