FOS

Gene Symbol	FOS
Entrez Gene	2353
Alt Symbol	AP-1, C-FOS, p55
Species	Human
Gene Type	protein-coding
Description	FBJ murine osteosarcoma viral oncogene homolog
Other Description	FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos
Swissprots	B4DQ65 P01100 P18849 A8K4E2
Accessions	AAA52471 AAC98315 AAO21129 BAA87920 BAA87921 CAA24756 CBX47570 EAW81227 EAW81228 EAW81229 P01100 AK097379 BAG53458 AK290907 BAF83596 AK291326 BAF84015 AK298659 BAG60827 BC004490 AAH04490 BX647104 CR541785 CAG46584 CR542267 CAG47063 DQ893444 ABM84370 DQ896750 ABM87749 S65138 AAB20306 NM_005252 NP_005243
Function	Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.
Subcellular Location	Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Top Pathways	Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SimpleChIP ® Human c-Fos Exon 3 Primers - 12010 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

SimpleChIP ® Human c-Fos Promoter Primers - 4663 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Human FOS / c-FOS ELISA Kit (Sandwich ELISA) - LS-F4533 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat FOS / c-FOS ELISA Kit (Sandwich ELISA) - LS-F4998 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 0.156-10 ng/ml

Mouse FOS / c-FOS ELISA Kit (Sandwich ELISA) - LS-F4999 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.063 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat FOS / c-FOS ELISA Kit (DNA-Binding ELISA) - LS-F733 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-FOS / c-FOS (Ser362) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1133 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-FOS / c-FOS (Ser32) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1706 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-FOS / c-FOS (Thr232) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1710 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat FOS / c-FOS ELISA Kit (Cell-Based ELISA) - LS-F1996 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse FOS / c-FOS ELISA Kit (Sandwich ELISA) - LS-F11483 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Rat FOS / c-FOS ELISA Kit (Sandwich ELISA) - LS-F11484 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.156-10 ng/ml

Human c-fos ELISA Kit - abx051282 from Abbexa Category ELISA Kit Sensitivity 8 pg/ml Range 33 pg/ml - 2000 pg/ml

Human FOS ELISA Kit - abx151580 from Abbexa Category ELISA Kit Sensitivity 0.064 ng/ml Range 0.156 ng/ml - 10 ng/ml

V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog, FOS, Human, ELISA Kit - E-EL-H0695 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

C-Fos, Human, ELISA Kit - E01C0735 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

C-Fos, Human, ELISA Kit - YHB0678Hu from ARP American Research Products Category ELISA Kit

Proto-oncogene c-Fos, FOS, Human, ELISA Kit - E1291h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS), Human, ELISA Kit - SEB291Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.064ng/mL Range 0.156-10ng/mL

V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog, FOS, Mouse, ELISA Kit - E-EL-M1235 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

FOS, V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog, Rat, ELISA Kit - E-EL-R0183 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

FOS (V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog), Rat, ELISA Kit - E-EL-R1064 from ARP American Research Products Category ELISA Kit Prices $617.40 Sizes 96 t Sensitivity 0.094 ng/mL Range 0.156-10ng/mL

C-fos, Rabbit, ELISA Kit - E-EL-RB1778 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

C-fos, Chicken, ELISA Kit - E-EL-Ch1924 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

C-fos, Porcine, ELISA Kit - E-EL-P0331 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

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