Gene Symbol | FOS |
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Entrez Gene | 2353 |
Alt Symbol | AP-1, C-FOS, p55 |
Species | Human |
Gene Type | protein-coding |
Description | FBJ murine osteosarcoma viral oncogene homolog |
Other Description | FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos |
Swissprots | B4DQ65 P01100 P18849 A8K4E2 |
Accessions | AAA52471 AAC98315 AAO21129 BAA87920 BAA87921 CAA24756 CBX47570 EAW81227 EAW81228 EAW81229 P01100 AK097379 BAG53458 AK290907 BAF83596 AK291326 BAF84015 AK298659 BAG60827 BC004490 AAH04490 BX647104 CR541785 CAG46584 CR542267 CAG47063 DQ893444 ABM84370 DQ896750 ABM87749 S65138 AAB20306 NM_005252 NP_005243 |
Function | Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. |
Subcellular Location | Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30. |
Top Pathways | Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway |
Phospho-c-Fos (Ser32) (D82C12) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 8709 from Cell Signaling Technology
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Phospho-c-Fos (Ser32) (D82C12) XP ® Rabbit mAb (PE Conjugate) - 11919 from Cell Signaling Technology
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Phospho-c-Fos (Ser32) (D82C12) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 8677 from Cell Signaling Technology
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Phospho-c-Fos (Ser32) (D82C12) XP ® Rabbit mAb - 5348 from Cell Signaling Technology
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c-Fos (9F6) Rabbit mAb - 2250 from Cell Signaling Technology
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c-Fos Antibody - 4384 from Cell Signaling Technology
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c-Fos (4) - sc-52 from Santa Cruz Biotechnology
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c-Fos (4-10G) - sc-413 from Santa Cruz Biotechnology
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c-Fos (6-2H-2F) - sc-447 from Santa Cruz Biotechnology
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c-Fos (C-10) - sc-271243 from Santa Cruz Biotechnology
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c-Fos (E-8) - sc-166940 from Santa Cruz Biotechnology
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c-Fos (H-125) - sc-7202 from Santa Cruz Biotechnology
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c-Fos (D-1) - sc-8047 from Santa Cruz Biotechnology
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c-Fos (K-25) - sc-253 from Santa Cruz Biotechnology
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c-Fos (554C1a) - sc-81209 from Santa Cruz Biotechnology
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p-c-Fos (34E4) - sc-81485 from Santa Cruz Biotechnology
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p-c-Fos (Thr 232) - sc-130181 from Santa Cruz Biotechnology
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Anti-c-Fos (phospho S32) antibody - ab79319 from Abcam
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Anti-c-Fos (phospho S362) antibody - ab63444 from Abcam
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Anti-c-Fos (phospho S362) antibody - ab192442 from Abcam
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Anti-c-Fos (phospho T232) antibody - ab17933 from Abcam
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Anti-c-Fos (phospho T232) antibody - ab43175 from Abcam
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Anti-c-Fos (phospho T232) antibody - ab193365 from Abcam
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Anti-c-Fos (phospho T232) antibody - ab138471 from Abcam
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Anti-c-Fos (phospho T325) antibody - ab27793 from Abcam
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