FOS
| Gene Symbol | FOS |
|---|---|
| Entrez Gene | 2353 |
| Alt Symbol | AP-1, C-FOS, p55 |
| Species | Human |
| Gene Type | protein-coding |
| Description | FBJ murine osteosarcoma viral oncogene homolog |
| Other Description | FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos |
| Swissprots | B4DQ65 P01100 P18849 A8K4E2 |
| Accessions | AAA52471 AAC98315 AAO21129 BAA87920 BAA87921 CAA24756 CBX47570 EAW81227 EAW81228 EAW81229 P01100 AK097379 BAG53458 AK290907 BAF83596 AK291326 BAF84015 AK298659 BAG60827 BC004490 AAH04490 BX647104 CR541785 CAG46584 CR542267 CAG47063 DQ893444 ABM84370 DQ896750 ABM87749 S65138 AAB20306 NM_005252 NP_005243 |
| Function | Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. |
| Subcellular Location | Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30. |
| Top Pathways | Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway |
c-Fos CRISPR/Cas9 KO Plasmid (h) - sc-400009 from Santa Cruz Biotechnology
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c-Fos HDR Plasmid (h) - sc-400009-HDR from Santa Cruz Biotechnology
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c-Fos Double Nickase Plasmid (h) - sc-400009-NIC from Santa Cruz Biotechnology
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c-Fos Double Nickase Plasmid (h2) - sc-400009-NIC-2 from Santa Cruz Biotechnology
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c-Fos CRISPR Activation Plasmid (h) - sc-400009-ACT from Santa Cruz Biotechnology
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c-Fos CRISPR Activation Plasmid (h2) - sc-400009-ACT-2 from Santa Cruz Biotechnology
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c-Fos Lentiviral Activation Particles (h) - sc-400009-LAC from Santa Cruz Biotechnology
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c-Fos Lentiviral Activation Particles (h2) - sc-400009-LAC-2 from Santa Cruz Biotechnology
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c-Fos siRNA (h) - sc-29221 from Santa Cruz Biotechnology
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c-Fos shRNA Plasmid (h) - sc-29221-SH from Santa Cruz Biotechnology
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c-Fos shRNA (h) Lentiviral Particles - sc-29221-V from Santa Cruz Biotechnology
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c-Fos siRNA (h2) - sc-44200 from Santa Cruz Biotechnology
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c-Fos shRNA Plasmid (h2) - sc-44200-SH from Santa Cruz Biotechnology
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c-Fos shRNA (h2) Lentiviral Particles - sc-44200-V from Santa Cruz Biotechnology
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c-Fos siRNA (chicken) - sc-270088 from Santa Cruz Biotechnology
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c-Fos shRNA Plasmid (chicken) - sc-270088-SH from Santa Cruz Biotechnology
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c-Fos RNAi - H00002353-R01 from Novus Biologicals
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MISSION® esiRNA - EHU034291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1397 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1398 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1397 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1398 from Sigma-Aldrich
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FOS siRNA (Human) - CRH1644 from Cohesion Biosciences
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FOS - MBS8238706 from MyBioSource
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FOS shRNA Plasmid (Human) - CHH1644 from Cohesion Biosciences
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