FOS

Gene Symbol	FOS
Entrez Gene	2353
Alt Symbol	AP-1, C-FOS, p55
Species	Human
Gene Type	protein-coding
Description	FBJ murine osteosarcoma viral oncogene homolog
Other Description	FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos
Swissprots	B4DQ65 P01100 P18849 A8K4E2
Accessions	AAA52471 AAC98315 AAO21129 BAA87920 BAA87921 CAA24756 CBX47570 EAW81227 EAW81228 EAW81229 P01100 AK097379 BAG53458 AK290907 BAF83596 AK291326 BAF84015 AK298659 BAG60827 BC004490 AAH04490 BX647104 CR541785 CAG46584 CR542267 CAG47063 DQ893444 ABM84370 DQ896750 ABM87749 S65138 AAB20306 NM_005252 NP_005243
Function	Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.
Subcellular Location	Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Top Pathways	Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

c-Fos peptide - ab7997 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human c-Fos (phospho T232) peptide - ab43652 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human c-Fos full length protein - ab56280 from Abcam Category Protein Prices $376.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human c-Fos full length protein - ab84143 from Abcam Category Protein Prices $297.00 Sizes 5 µg Source Baculovirus Species Human

Human c-Fos peptide - ab60297 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E10540 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E10767 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E10766 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E8311 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E7342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E11402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOS / c-FOS Antibody Blocking Peptide - LS-E27980 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human c-Fos Protein - H00002353-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human c-Fos Protein - H00002353-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

c-Fos Peptide - P1467 from Novus Biologicals Category Peptide Species Human

Phospho-FOST232-Antibody-Blocking-peptide - BP3314a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

c-fos-Antibody-C-term-Blocking-Peptide - BP6585b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOS peptide - orb217301 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Drosophila, Sheep

c-FOS Blocking Peptide - abx062632 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig, Sheep

C-Fos Peptide - AC21-2742-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

c-fos - H00002353-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

c-fos - H00002353-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

c-fos - H00002353-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

c-fos - H00002353-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

c-fos Control Peptide - 24338 from Acris Antibodies Category Peptide Prices $135.00 Sizes 25 µg

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