FZD3

Gene Symbol FZD3
Entrez Gene 7976
Alt Symbol Fz-3
Species Human
Gene Type protein-coding
Description frizzled class receptor 3
Other Description frizzled 3, seven transmembrane spanning receptor|frizzled family receptor 3|frizzled homolog 3|frizzled-3
Swissprots A8K615 Q9NPG1
Accessions EAW63511 Q9NPG1 AB039723 BAA94968 AJ272427 CAB89114 AK291480 BAF84169 AY005130 AAF89088 BC034278 BC042009 BC156293 AAI56294 BC172481 AAI72481 BU676090 DA250029 XM_011544646 XP_011542948 XM_011544647 XP_011542949 XM_011544648 XP_011542950 XM_011544649 XP_011542951 XR_949476 XR_949477 XR_949478 NM_017412 NP_059108 NM_145866 NP_665873
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Requ
Subcellular Location Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}.
Tissue Specificity Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
Top Pathways Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Hippo signaling pathway

frizzled-3 (C-1) - sc-376105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
frizzled-3 (C-1): sc-376105. Western blot analysis of frizzled-3 expression in Y79 whole cell lysate.

frizzled-3 (N-18) - sc-68334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-3 (N-18): sc-68334. Western blot analysis of frizzled-3 expression in Y79 whole cell lysate.

frizzled-3 (E-17) - sc-68332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

frizzled-3 (H-166) - sc-292246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

frizzled-3 (H-20) - sc-68333 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-3 (H-20): sc-68333. Western blot analysis of frizzled-3 expression in HeLa whole cell lysate.

Anti-FZD3 antibody - ab75233 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75233 at 1/500 dilution staining FZD3 in A549 cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-FZD3 antibody - ab56331 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56331 FZD3 antibody at 1ug/ml.

Anti-FZD3 antibody - ab197046 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain (cortex) tissue, labeling FZD3 with ab197046 at 20 µg/ml.

Anti-FZD3 antibody - C-terminal - ab138558 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FZD3 antibody - C-terminal (ab138558) at 1/100 dilution + CEM cell lysate at 35 µg

Anti-FZD3 / Frizzled 3 Antibody (N-Terminus) IHC-plus™ - LS-A4437 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD3 / Frizzled 3 antibody LS-A4437 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD3 / Frizzled 3 Antibody IHC-plus™ - LS-A4454 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD3 / Frizzled 3 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD3 / Frizzled 3 Antibody - LS-C23706 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-FZD3 / Frizzled 3 Antibody - LS-C23708 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-FZD3 / Frizzled 3 Antibody (Biotin) - LS-C23709 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-FZD3 / Frizzled 3 Antibody (aa569-581) - LS-C87247 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FZD3 / Frizzled 3 Antibody (Leu180) - LS-C177091 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Frizzled-3 (L180) pAb in extracts from A549 cells.

Anti-FZD3 / Frizzled 3 Antibody (Arg524) - LS-C177199 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Frizzled-3 (R524) pAb in extracts from HUVEC cells.

Anti-FZD3 / Frizzled 3 Antibody (aa496-525) - LS-C159691 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FZD3 Antibody western blot of CEM cell line lysates (35 ug/lane). The FZD3 antibody detected the FZD3 protein (arrow).

Anti-FZD3 / Frizzled 3 Antibody (C-Terminus) - LS-C210098 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD3 / Frizzled 3 Antibody (aa141-190) - LS-C120595 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, using FZD3 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FZD3 / Frizzled 3 Antibody (aa496-525, AP) - LS-C257475 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD3 / Frizzled 3 Antibody (clone 1B8) - LS-C198515 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B8
Detection limit for recombinant GST tagged FZD3 is approximately 1 ng/ml as a capture antibody.

Anti-FZD3 / Frizzled 3 Antibody (aa496-525, APC) - LS-C257476 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD3 / Frizzled 3 Antibody (aa496-525, Biotin) - LS-C257478 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD3 / Frizzled 3 Antibody (aa496-525, FITC) - LS-C257479 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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