| Gene Symbol | FZD3 |
|---|---|
| Entrez Gene | 7976 |
| Alt Symbol | Fz-3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 3 |
| Other Description | frizzled 3, seven transmembrane spanning receptor|frizzled family receptor 3|frizzled homolog 3|frizzled-3 |
| Swissprots | A8K615 Q9NPG1 |
| Accessions | EAW63511 Q9NPG1 AB039723 BAA94968 AJ272427 CAB89114 AK291480 BAF84169 AY005130 AAF89088 BC034278 BC042009 BC156293 AAI56294 BC172481 AAI72481 BU676090 DA250029 XM_011544646 XP_011542948 XM_011544647 XP_011542949 XM_011544648 XP_011542950 XM_011544649 XP_011542951 XR_949476 XR_949477 XR_949478 NM_017412 NP_059108 NM_145866 NP_665873 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Requ |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}. |
| Tissue Specificity | Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. |
| Top Pathways | Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Hippo signaling pathway |