FZD3

Gene Symbol	FZD3
Entrez Gene	7976
Alt Symbol	Fz-3
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 3
Other Description	frizzled 3, seven transmembrane spanning receptor|frizzled family receptor 3|frizzled homolog 3|frizzled-3
Swissprots	A8K615 Q9NPG1
Accessions	EAW63511 Q9NPG1 AB039723 BAA94968 AJ272427 CAB89114 AK291480 BAF84169 AY005130 AAF89088 BC034278 BC042009 BC156293 AAI56294 BC172481 AAI72481 BU676090 DA250029 XM_011544646 XP_011542948 XM_011544647 XP_011542949 XM_011544648 XP_011542950 XM_011544649 XP_011542951 XR_949476 XR_949477 XR_949478 NM_017412 NP_059108 NM_145866 NP_665873
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Requ
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}.
Tissue Specificity	Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
Top Pathways	Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Human FZD3 / Frizzled 3 ELISA Kit (Sandwich ELISA) - LS-F11500 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.78-50 ng/ml

Frizzled-3, FZD3, Human, ELISA Kit - E11111h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

frizzled homolog 3 (Drosophila) , ELISA Kit - MBS9325427 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzled Homolog 3 (FZD3), ELISA Kit - MBS9300151 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chicken FZD3 / Frizzled 3 ELISA Kit (Custom ELISA) - LS-F16051 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Mouse FZD3 / Frizzled 3 ELISA Kit (Custom ELISA) - LS-F16052 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Human Frizzled-3 ELISA Kit - abx250521 from Abbexa Category ELISA Kit Range 0.78 ng/ml - 50 ng/ml

Human Frizzled-3 ELISA Kit - EKE52723 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.23 ng/ml Range 0.78-50 ng/mL

FZD3 - EKH2520 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.78-50ng/ml

FZD3 ELISA Kit (Human) (OKEH02139) - OKEH02139 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.23 ng/mL Range 0.78 - 50 ng/mL

Human FZD3 ELISA Kit - E015588 from Biobool Category ELISA Kit Sensitivity <0.469ng/ml

Human Frizzled-3 ELISA Kit - EK2767 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.23 ng/ml Range 0.78-50 ng/mL

Frizzled-3, ELISA Kit - MBS761860 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/ml Range 0.78-50ng/ml

Frizzled-3, ELISA Kit - MBS9426604 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.23 ng/mL Range 0.78-50 ng/mL

Frizzled-3, ELISA Kit - MBS2881222 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.78-50 ng/mL

Human FZD3 / Frizzled 3 ELISA Kit (Sandwich ELISA) - LS-F33830 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.469 Range 0.78-50 ng/ml

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