FZD3

Gene Symbol	FZD3
Entrez Gene	7976
Alt Symbol	Fz-3
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 3
Other Description	frizzled 3, seven transmembrane spanning receptor|frizzled family receptor 3|frizzled homolog 3|frizzled-3
Swissprots	A8K615 Q9NPG1
Accessions	EAW63511 Q9NPG1 AB039723 BAA94968 AJ272427 CAB89114 AK291480 BAF84169 AY005130 AAF89088 BC034278 BC042009 BC156293 AAI56294 BC172481 AAI72481 BU676090 DA250029 XM_011544646 XP_011542948 XM_011544647 XP_011542949 XM_011544648 XP_011542950 XM_011544649 XP_011542951 XR_949476 XR_949477 XR_949478 NM_017412 NP_059108 NM_145866 NP_665873
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Requ
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}.
Tissue Specificity	Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
Top Pathways	Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Human FZD3 protein fragment - ab152834 from Abcam Category Protein Source Wheat germ Species Human

FZD3 / Frizzled 3 Antibody Blocking Peptide - LS-E6070 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD3 / Frizzled 3 Antibody Blocking Peptide - LS-E28961 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD3 / Frizzled 3 Antibody Blocking Peptide - LS-E28962 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD3 / Frizzled 3 Antibody Blocking Peptide - LS-E28965 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD3 / Frizzled 3 Antibody Blocking Peptide - LS-E26661 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Frizzled-3 Protein - H00007976-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FZD3-Antibody-C-term-Blocking-Peptide - BP18664b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Frizzled 3 blocking peptide - GTX88713-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

FZD3 Peptide - AC21-1498-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Frizzled 3 Peptide - 46-845P from ProSci Category Peptide

FZD3 fusion protein - ag18213 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FZD3 fusion protein - ag18324 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human FZD3, GST-tagged - FZD3-13066H from Creative Biomart Category Protein Source E.coli Species Human

Frizzled-3 (L180) Peptide - BS2602P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Frizzled-3 (R524) Peptide - BS2794P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Frizzled 3, Peptide - MBS426098 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

Frizzled-3 (FZD3), Recombinant Protein - MBS7015400 from MyBioSource Category Protein Prices $1,435.00, $2,420.00, $3,625.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Frizzled-3 Recombinant Protein Antigen - NBP2-59006PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

FZD3 Immunizing peptide - orb50461 from Biorbyt Category Peptide

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