EPHA2

Gene Symbol	EPHA2
Entrez Gene	1969
Alt Symbol	ARCC2, CTPA, CTPP1, CTRCT6, ECK
Species	Human
Gene Type	protein-coding
Description	EPH receptor A2
Other Description	ephrin type-A receptor 2|epithelial cell receptor protein tyrosine kinase|soluble EPHA2 variant 1|tyrosine-protein kinase receptor ECK
Swissprots	B5A968 Q8N3Z2 P29317
Accessions	AAL11019 CAI61887 CAM91182 CAT16927 CAV28316 CBX51742 EAW51769 EAW51770 P29317 AI302504 AK296788 BAG59366 BC008655 AAH08655 BC037166 AAH37166 CB991812 DQ895231 ABM86157 EU176326 ABW03777 EU826606 ACF47642 M59371 AAA53375 NM_004431 NP_004422
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single- pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
Tissue Specificity	Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary. {ECO:0000269|PubMed:17332925}.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPHA2 293T Cell Transient Overexpression Lysate(Denatured) - H00001969-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

EPHA2 293T Cell Transient Overexpression Lysate(Denatured) - H00001969-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

EphA2 Overexpression Lysate (Denatured) - H00001969-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human EphA2 HEK293 Cell Lysate (WB positive control) - 13926-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

EphA2 Overexpression Lysate (Native) - NBP2-10583 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

EphA2 Overexpression Lysate (Denatured) - H00001969-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human EPHA2 Human Cells Transfected Lysate (positive control) (denatured) - orb174596 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

EPHA2-knockout Cell lysate - LC810063 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Human EPHA2 Knockout Cell Line-HeLa - CSC-RT0549 from Creative biogene Category Cell Line Species Human

EPHA2 Knockout Cell Line-HCT116 - CSC-RT1878 from Creative biogene Category Cell Line Species Human

EPHA2 KO Cell Lysate-HeLa - CLKO-0054 from Creative biogene Category Cell Lysate

EPHA2 KO Cell Lysate-HCT116 - CLKO-1732 from Creative biogene Category Cell Lysate

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