EPHA2

Gene Symbol	EPHA2
Entrez Gene	1969
Alt Symbol	ARCC2, CTPA, CTPP1, CTRCT6, ECK
Species	Human
Gene Type	protein-coding
Description	EPH receptor A2
Other Description	ephrin type-A receptor 2|epithelial cell receptor protein tyrosine kinase|soluble EPHA2 variant 1|tyrosine-protein kinase receptor ECK
Swissprots	B5A968 Q8N3Z2 P29317
Accessions	AAL11019 CAI61887 CAM91182 CAT16927 CAV28316 CBX51742 EAW51769 EAW51770 P29317 AI302504 AK296788 BAG59366 BC008655 AAH08655 BC037166 AAH37166 CB991812 DQ895231 ABM86157 EU176326 ABW03777 EU826606 ACF47642 M59371 AAA53375 NM_004431 NP_004422
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single- pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
Tissue Specificity	Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary. {ECO:0000269|PubMed:17332925}.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Eph receptor A2 full length protein - ab114439 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor A2 protein fragment - ab114440 from Abcam Category Protein Source Wheat germ Species Human

EPHA2 / EPH Receptor A2 Antibody Blocking Peptide - LS-E3440 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA2 / EPH Receptor A2 Antibody Blocking Peptide - LS-E7467 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA2 / EPH Receptor A2 Antibody Blocking Peptide - LS-E9098 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA2 / EPH Receptor A2 Antibody Blocking Peptide - LS-E9099 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EphA2 Protein - H00001969-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EphA2 Partial Recombinant Protein - H00001969-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EphA2 Recombinant Protein - P4677 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

EphA2 Peptide - P2618 from Novus Biologicals Category Peptide Species Human

EphA2 Peptide - P2617 from Novus Biologicals Category Peptide Species Human

Phospho-EphA2S897-Antibody-Blocking-peptide - BP3722a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

EphA2-Antibody-C-term-Blocking-Peptide - BP7607b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EphA2-Antibody-N-term-Blocking-Peptide - BP7607a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human EphA2, CF - 3035-A2-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln25-Asn534, with a C-terminal 6-His tag

Human EPH receptor A2 protein - orb138771 from Biorbyt Category Protein Prices $570.00, $663.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

Human EPH receptor A2 protein - orb138772 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells Species Human

EPHA2 Blocking Peptide - abx062571 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

EPHA2 / ECK - H00001969-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

EPHA2 / ECK - H00001969-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EPHA2 / ECK - H00001969-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHA2 / ECK - H00001969-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHA2 / ECK - P4677 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

EPHA2 / ECK - P5703 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

EPHA2 fusion protein - ag2221 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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