EPHA2

Gene Symbol	EPHA2
Entrez Gene	1969
Alt Symbol	ARCC2, CTPA, CTPP1, CTRCT6, ECK
Species	Human
Gene Type	protein-coding
Description	EPH receptor A2
Other Description	ephrin type-A receptor 2|epithelial cell receptor protein tyrosine kinase|soluble EPHA2 variant 1|tyrosine-protein kinase receptor ECK
Swissprots	B5A968 Q8N3Z2 P29317
Accessions	AAL11019 CAI61887 CAM91182 CAT16927 CAV28316 CBX51742 EAW51769 EAW51770 P29317 AI302504 AK296788 BAG59366 BC008655 AAH08655 BC037166 AAH37166 CB991812 DQ895231 ABM86157 EU176326 ABW03777 EU826606 ACF47642 M59371 AAA53375 NM_004431 NP_004422
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single- pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
Tissue Specificity	Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary. {ECO:0000269|PubMed:17332925}.
Top Pathways	Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-EphA2 (Ser897) (D9A1) Rabbit mAb - 6347 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D9A1

Phospho-EphA2 (Tyr594) Antibody - 3970 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb - 12677 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D7X2L

Phospho-EphA2 (Tyr772) Antibody - 8244 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

EphA2 (D4A2) XP ® Rabbit mAb - 6997 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D4A2

EphA2 (8B6) Mouse mAb - 12927 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 8B6

Phospho-EphA2 (Tyr588) Antibody - 7423 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

EphA2 Antibody - 3974 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

EphA2 (C-20) - sc-924 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EphA2 (C-3) - sc-398832 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EphA2 (F-14) - sc-31255 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphA2 (Kα-5H5) - sc-101377 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EphA2 (N-14) - sc-31254 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphA2 (H-77) - sc-10746 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EphA2 (3D7) - sc-135658 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/500 µl Host Mouse Clonality Monoclonal

Anti-Eph receptor A2+A3+A4 (phospho Y588 + Y596) antibody - ab62256 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2+A3+A4 antibody - ab196899 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2+A3+A4 antibody - ab61160 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2 antibody - ab5386 from Abcam Prices $390.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2 antibody - ab5387 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2 antibody - ab110690 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2 antibody - ab196887 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Eph receptor A2 antibody - ab54968 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Eph receptor A2 antibody [3D7] - ab118882 from Abcam Prices $384.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3D7

Anti-Eph receptor A2 antibody [EP4760] - ab133501 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP4760

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