EPHA2
| Gene Symbol | EPHA2 |
|---|---|
| Entrez Gene | 1969 |
| Alt Symbol | ARCC2, CTPA, CTPP1, CTRCT6, ECK |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A2 |
| Other Description | ephrin type-A receptor 2|epithelial cell receptor protein tyrosine kinase|soluble EPHA2 variant 1|tyrosine-protein kinase receptor ECK |
| Swissprots | B5A968 Q8N3Z2 P29317 |
| Accessions | AAL11019 CAI61887 CAM91182 CAT16927 CAV28316 CBX51742 EAW51769 EAW51770 P29317 AI302504 AK296788 BAG59366 BC008655 AAH08655 BC037166 AAH37166 CB991812 DQ895231 ABM86157 EU176326 ABW03777 EU826606 ACF47642 M59371 AAA53375 NM_004431 NP_004422 |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single- pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells. |
| Tissue Specificity | Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary. {ECO:0000269|PubMed:17332925}. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
EphA2 CRISPR/Cas9 KO Plasmid (h) - sc-400535 from Santa Cruz Biotechnology
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EphA2 HDR Plasmid (h) - sc-400535-HDR from Santa Cruz Biotechnology
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EphA2 Double Nickase Plasmid (h) - sc-400535-NIC from Santa Cruz Biotechnology
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EphA2 Double Nickase Plasmid (h2) - sc-400535-NIC-2 from Santa Cruz Biotechnology
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EphA2 CRISPR Activation Plasmid (h) - sc-400535-ACT from Santa Cruz Biotechnology
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EphA2 CRISPR Activation Plasmid (h2) - sc-400535-ACT-2 from Santa Cruz Biotechnology
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EphA2 Lentiviral Activation Particles (h) - sc-400535-LAC from Santa Cruz Biotechnology
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EphA2 Lentiviral Activation Particles (h2) - sc-400535-LAC-2 from Santa Cruz Biotechnology
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EphA2 siRNA (h) - sc-29304 from Santa Cruz Biotechnology
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EphA2 shRNA Plasmid (h) - sc-29304-SH from Santa Cruz Biotechnology
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EphA2 shRNA (h) Lentiviral Particles - sc-29304-V from Santa Cruz Biotechnology
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EphA2 RNAi - H00001969-R04 from Novus Biologicals
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MISSION® esiRNA - EHU075051 from Sigma-Aldrich
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MISSION® siRNA - SIHK0684 from Sigma-Aldrich
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MISSION® siRNA - SIHK0686 from Sigma-Aldrich
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MISSION® siRNA - SIHK0685 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2219 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2219 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06558 from Sigma-Aldrich
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EPHA2 siRNA (Human) - CRH1363 from Cohesion Biosciences
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EPHA2 - MBS8221296 from MyBioSource
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EphA2 CRISPR/Cas9 KO Plasmid (h2) - sc-400535-KO-2 from Santa Cruz Biotechnology
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EphA2 HDR Plasmid (h2) - sc-400535-HDR-2 from Santa Cruz Biotechnology
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Human EPHA2 siRNA - orb261865 from Biorbyt
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EPHA2 shRNA Plasmid (Human) - CHH1363 from Cohesion Biosciences
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