| Gene Symbol |
SNRPC
|
| Entrez Gene |
6631
|
| Alt Symbol |
U1C, Yhc1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein polypeptide C
|
| Other Description |
U1 small nuclear RNP specific C|U1 small nuclear ribonucleoprotein C|U1 snRNP C|U1 snRNP protein C|U1-C|U1C
|
| Swissprots |
P09234 Q5TAL3
|
| Accessions |
CAJ42725 EAX03795 EAX03796 EAX03797 P09234 AI356808 AK223098 BAD96818 AK311955 BAG34895 BC121082 AAI21083 BC121083 AAI21084 BU153661 BU508721 CD109745 M18465 AAA36618 X12517 CAA31037 NM_003093 NP_003084 NR_029472
|
| Function |
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Spliceosome
|
