Gene Symbol | SNRPC |
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Entrez Gene | 6631 |
Alt Symbol | U1C, Yhc1 |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein polypeptide C |
Other Description | U1 small nuclear RNP specific C|U1 small nuclear ribonucleoprotein C|U1 snRNP C|U1 snRNP protein C|U1-C|U1C |
Swissprots | P09234 Q5TAL3 |
Accessions | CAJ42725 EAX03795 EAX03796 EAX03797 P09234 AI356808 AK223098 BAD96818 AK311955 BAG34895 BC121082 AAI21083 BC121083 AAI21084 BU153661 BU508721 CD109745 M18465 AAA36618 X12517 CAA31037 NM_003093 NP_003084 NR_029472 |
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}. |
Subcellular Location | Nucleus. |
Top Pathways | Spliceosome |
SNRPC (C-2) - sc-374428 from Santa Cruz Biotechnology
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SNRPC (E-10) - sc-376552 from Santa Cruz Biotechnology
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SNRPC (E-14) - sc-169379 from Santa Cruz Biotechnology
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SNRPC (5C9) - sc-101548 from Santa Cruz Biotechnology
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SNRPC (H-70) - sc-292035 from Santa Cruz Biotechnology
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SNRPC (4H12) - sc-101549 from Santa Cruz Biotechnology
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Anti-SNRPC [EPR16034] antibody - ab192028 from Abcam
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Anti-SNRPC antibody [4H12] - ab122901 from Abcam
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Anti-SNRPC antibody - C-terminal - ab82862 from Abcam
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Anti-SNRPC / U1C Antibody (aa2-159) - LS-C314768 from LifeSpan Bioscience
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Anti-SNRPC / U1C Antibody (aa133-159) - LS-C97332 from LifeSpan Bioscience
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Anti-SNRPC / U1C Antibody (aa109-159) - LS-C290590 from LifeSpan Bioscience
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SNRPC Antibody - NBP2-38755 from Novus Biologicals
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SNRPC Antibody - NBP2-22299 from Novus Biologicals
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Monoclonal Anti-U1 snRNP C (U1C) antibody produced in rat - SAB4200188 from Sigma-Aldrich
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Anti-SNRPC (C-term) antibody produced in rabbit - SAB1300710 from Sigma-Aldrich
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ANTI-SNRPC(C-TERMINAL) antibody produced in rabbit - SAB1307173 from Sigma-Aldrich
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SNRPC Antibody - C-terminal region (OAAB01572) - OAAB01572 from Aviva Systems Biology
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SNRPC-Antibody-C-term - AP2841b from Abgent, a WuXi AppTec company
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snRNP-C / SNRPC (C-term) antibody - AP12499PU-N from Acris Antibodies
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Rabbit Anti-Human SNRPC (C-term) - 102-15178 from RayBiotech
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SNRPC antibody (C-term) - STJ48636 from St John's Laboratory Ltd
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SNRPC, Polyclonal Antibody - MBS630773 from MyBioSource
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Anti-SNRPC (aa 109-159) polyclonal antibody - DPABH-05777 from Creative Diagnostics
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U1C Antibody - A303-947A from Bethyl Labs
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