RAB8A

Gene Symbol	RAB8A
Entrez Gene	4218
Alt Symbol	MEL, RAB8
Species	Human
Gene Type	protein-coding
Description	RAB8A, member RAS oncogene family
Other Description	mel transforming oncogene (RAB8 homolog)|mel transforming oncogene (derived from cell line NK14)|mel transforming oncogene (derived from cell line NK14)- RAB8 homolog|oncogene c-mel|ras-associated protein RAB8|ras-related protein Rab-8A
Swissprots	B4DEK7 P61006 Q6FHV5 P24407
Accessions	AAB19681 EAW84526 EAW84527 P61006 AB209767 BAD93004 AF498943 AAM21091 AK025165 AK293676 BAG57118 BC002977 AAH02977 BT007184 AAP35848 BU940750 CR536583 CAG38820 CR542274 CAG47070 DQ892523 ABM83449 DQ895735 ABM86661 X56741 CAA40065 XM_011528020 XP_011526322 NM_005370 NP_005361
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucos
Subcellular Location	Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus. Recycling endosome membrane. Cell projection, cilium. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP- bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP- bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis.
Top Pathways	Pancreatic secretion, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAB8A full length protein - ab116785 from Abcam Category Protein Source Wheat germ Species Human

Human RAB8A protein fragment - ab152526 from Abcam Category Protein Source Wheat germ Species Human

RAB8A / RAB8 Antibody Blocking Peptide - LS-E10707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAB8A / RAB8 Antibody Blocking Peptide - LS-E26602 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RAB8A Protein - H00004218-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RAB8A Protein - H00004218-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAB8A blocking peptide - GTX88822-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Human MEL protein - orb245232 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

RAB8A Blocking Peptide - 33R-3327 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAB8A Peptide - AC21-1438-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RAB8A - H00004218-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB8A - H00004218-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB8A - H00004218-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB8A - H00004218-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB8A Peptide - 46-703P from ProSci Category Peptide Species Human

RAB8A fusion protein - ag0702 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RAB8A - RAB8A-29054TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human RAB8A, GST-tagged - RAB8A-2135H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RAB8A - RAB8A-311H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant human Ras-related protein Rab-8A protein - CSB-EP051744h CSB-BP051744h CSB-MP051744h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Ras-related protein Rab-8A(RAB8A),partial - CSB-RP051744h from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Ras-related protein Rab-8A(RAB8A) - CSB-YP019222HU CSB-EP019222HU CSB-BP019222HU CSB-MP019222HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAB8A Peptide - abx164662 from Abbexa Category Peptide Species Human, Mouse, Rat

RAB8A - TP300675 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RAB8A, Peptide - MBS426539 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

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