RAB8A

Gene Symbol	RAB8A
Entrez Gene	4218
Alt Symbol	MEL, RAB8
Species	Human
Gene Type	protein-coding
Description	RAB8A, member RAS oncogene family
Other Description	mel transforming oncogene (RAB8 homolog)|mel transforming oncogene (derived from cell line NK14)|mel transforming oncogene (derived from cell line NK14)- RAB8 homolog|oncogene c-mel|ras-associated protein RAB8|ras-related protein Rab-8A
Swissprots	B4DEK7 P61006 Q6FHV5 P24407
Accessions	AAB19681 EAW84526 EAW84527 P61006 AB209767 BAD93004 AF498943 AAM21091 AK025165 AK293676 BAG57118 BC002977 AAH02977 BT007184 AAP35848 BU940750 CR536583 CAG38820 CR542274 CAG47070 DQ892523 ABM83449 DQ895735 ABM86661 X56741 CAA40065 XM_011528020 XP_011526322 NM_005370 NP_005361
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucos
Subcellular Location	Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus. Recycling endosome membrane. Cell projection, cilium. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP- bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP- bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis.
Top Pathways	Pancreatic secretion, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rab8 (D22D8) XP ® Rabbit mAb - 6975 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D22D8

Rab8 Antibody - 4637 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

Rab 8 (FL-207) - sc-28572 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rab 8A (D-17) - sc-26578 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rab 8A (P-16) - sc-306 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rab 8A (63-BJ) - sc-81909 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-RAB8A antibody - ab55891 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAB8A antibody [3G1] - ab192768 from Abcam Prices $407.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3G1

Anti-RAB8A antibody [6.4_1E6] - ab128022 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6.4_1E6

Anti-RAB8A antibody [EPR14873] - C-terminal - ab188574 from Abcam Prices $99.00, $357.00 Sizes 10 µl, 100 µl Host Rabbit Clonality Monoclonal Clone EPR14873

Anti-RAB8A antibody - N-terminal - ab170055 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAB8A / RAB8 Antibody (N-Terminus) - LS-C46957 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAB8A / RAB8 Antibody (aa108-207, Azide-free) - LS-C330622 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-RAB8A / RAB8 Antibody (C-Terminus) - LS-C102844 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAB8A / RAB8 Antibody - LS-C332678 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAB8A / RAB8 Antibody (aa186-198) - LS-C61782 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-RAB8A / RAB8 Antibody (clone 3G1) IHC-plus™ - LS-B10994 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3G1

Anti-RAB8A / RAB8 Antibody (C-Terminus) IHC-plus™ - LS-B9782 from LifeSpan Bioscience Prices $395.00 Sizes 300 µg Host Goat Clonality Polyclonal

Anti-RAB8A / RAB8 Antibody (aa170-183) - LS-C313375 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RAB8A Antibody (3G1) - H00004218-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G1

RAB8A Antibody - NBP1-79960 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAB8A Antibody - NB100-93433 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

RAB8A Polyclonal Antibody - bs-6176R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-RAB8A antibody produced in mouse - WH0004218M2 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G1

Anti-Rab8 antibody produced in rabbit - R5530 from Sigma-Aldrich Prices $346.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Search more