| Gene Symbol |
ZFYVE16
|
| Entrez Gene |
9765
|
| Alt Symbol |
PPP1R69
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, FYVE domain containing 16
|
| Other Description |
endosome-associated FYVE-domain protein|protein phosphatase 1, regulatory subunit 69|zinc finger FYVE domain-containing protein 16
|
| Swissprots |
Q8NEK3 Q7LAU7 Q7Z3T8 Q8N5L3 O15023 Q86T69 Q5H9U2
|
| Accessions |
EAW95850 EAW95851 Q7Z3T8 AB002303 BAA20764 AF434817 AAL30772 AK090896 AK127003 BAG54419 AL833087 CAD89968 AW952550 BC030808 AAH30808 BC032227 BX537424 CAD97666 BX649172 BX956000 CB854699 CR933621 CAI45932 DA216169 DB208042 DR005686 XM_005248632 XP_005248689 XM_005248634 XP_005248691 XM_011543752 XP_011542054 XM_011543753 XP_011542055 XM_011543754 XP_011542056 XM_011543755 XP_011542057 XM_011543756 XP_011542058 NM_001105251 NP_001098721 NM_001284236 NP_001271165 NM_001284237 NP_001271166 NM_014733 NP_055548
|
| Function |
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11546807}. Early endosome membrane {ECO:0000269|PubMed:11546807}; Peripheral membrane protein {ECO:0000269|PubMed:11546807}. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
|
| Tissue Specificity |
Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. {ECO:0000269|PubMed:11546807}.
|
| Top Pathways |
TGF-beta signaling pathway, Endocytosis
|