| Gene Symbol |
PIGZ
|
| Entrez Gene |
80235
|
| Alt Symbol |
GPI-MT-IV, PIG-Z, SMP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol glycan anchor biosynthesis, class Z
|
| Other Description |
GPI mannosyltransferase 4|GPI mannosyltransferase IV|SMP3 mannosyltransferase|dol-P-Man dependent GPI mannosyltransferase|phosphatidylinositol glycan, class Z|phosphatidylinositol-glycan biosynthesis class Z protein
|
| Swissprots |
Q86VD9 Q9H9G6
|
| Accessions |
EAW53618 Q86VD9 AK022830 BAB14263 AK296867 BAG59430 BC018804 BC044640 AAH44640 BG760692 BX493581 DA736224 XM_006713758 XP_006713821 XM_011513190 XP_011511492 XM_011513191 XP_011511493 XM_011513192 XP_011511494 NM_025163 NP_079439
|
| Function |
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. {ECO:0000269|PubMed:15208306}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15208306}; Multi-pass membrane protein {ECO:0000269|PubMed:15208306}.
|
| Tissue Specificity |
Widely expressed at low level, with highest level in brain and colon. {ECO:0000269|PubMed:15208306}.
|
| Top Pathways |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
|
![Western Blot: PIGZ Overexpression Lysate (Adult Normal) [NBP2-06234] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PIGZ.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5288_PIGZ%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06234-img0001.jpg)