Gene Symbol | PIGZ |
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Entrez Gene | 80235 |
Alt Symbol | GPI-MT-IV, PIG-Z, SMP3 |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol glycan anchor biosynthesis, class Z |
Other Description | GPI mannosyltransferase 4|GPI mannosyltransferase IV|SMP3 mannosyltransferase|dol-P-Man dependent GPI mannosyltransferase|phosphatidylinositol glycan, class Z|phosphatidylinositol-glycan biosynthesis class Z protein |
Swissprots | Q86VD9 Q9H9G6 |
Accessions | EAW53618 Q86VD9 AK022830 BAB14263 AK296867 BAG59430 BC018804 BC044640 AAH44640 BG760692 BX493581 DA736224 XM_006713758 XP_006713821 XM_011513190 XP_011511492 XM_011513191 XP_011511493 XM_011513192 XP_011511494 NM_025163 NP_079439 |
Function | Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. {ECO:0000269|PubMed:15208306}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15208306}; Multi-pass membrane protein {ECO:0000269|PubMed:15208306}. |
Tissue Specificity | Widely expressed at low level, with highest level in brain and colon. {ECO:0000269|PubMed:15208306}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
PIG-Z CRISPR/Cas9 KO Plasmid (h) - sc-413369 from Santa Cruz Biotechnology
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PIG-Z HDR Plasmid (h) - sc-413369-HDR from Santa Cruz Biotechnology
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PIG-Z Double Nickase Plasmid (h) - sc-413369-NIC from Santa Cruz Biotechnology
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PIG-Z Double Nickase Plasmid (h2) - sc-413369-NIC-2 from Santa Cruz Biotechnology
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PIG-Z CRISPR Activation Plasmid (h) - sc-413369-ACT from Santa Cruz Biotechnology
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PIG-Z CRISPR Activation Plasmid (h2) - sc-413369-ACT-2 from Santa Cruz Biotechnology
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PIG-Z Lentiviral Activation Particles (h) - sc-413369-LAC from Santa Cruz Biotechnology
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PIG-Z Lentiviral Activation Particles (h2) - sc-413369-LAC-2 from Santa Cruz Biotechnology
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PIG-Z siRNA (h) - sc-78225 from Santa Cruz Biotechnology
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PIG-Z shRNA Plasmid (h) - sc-78225-SH from Santa Cruz Biotechnology
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PIG-Z shRNA (h) Lentiviral Particles - sc-78225-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU030351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16803 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16803 from Sigma-Aldrich
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PIGZ siRNA (Human) - CRJ2821 from Cohesion Biosciences
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shRNA set against Human PIGZ (NM_025163.2) - SHH375604 from Creative biogene
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Human PIGZ siRNA - orb273322 from Biorbyt
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PIGZ shRNA Plasmid (Human) - CHJ2821 from Cohesion Biosciences
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PIGZ miRNA 3'UTR clone - MiUTR1H-07899 from Creative biogene
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