| Gene Symbol |
TSHZ3
|
| Entrez Gene |
57616
|
| Alt Symbol |
TSH3, ZNF537
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
teashirt zinc finger homeobox 3
|
| Other Description |
teashirt 3|teashirt family zinc finger 3|teashirt homolog 3|zinc finger protein 537
|
| Swissprots |
Q63HK5 Q9P254 Q9H0G6
|
| Accessions |
Q63HK5 AB040907 BAA95998 AI015687 AK291466 BAF84155 AK293267 BAG56797 AL136805 CAB66739 AM393571 CAL38448 BC127095 AAI27096 BC127096 AAI27097 BX648745 CAH56184 CN256026 NM_020856 NP_065907
|
| Function |
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. {ECO:0000269|PubMed:19343227}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease. {ECO:0000269|PubMed:18776146, ECO:0000269|PubMed:19343227}.
|