TSHZ3

Gene Symbol	TSHZ3
Entrez Gene	57616
Alt Symbol	TSH3, ZNF537
Species	Human
Gene Type	protein-coding
Description	teashirt zinc finger homeobox 3
Other Description	teashirt 3|teashirt family zinc finger 3|teashirt homolog 3|zinc finger protein 537
Swissprots	Q63HK5 Q9P254 Q9H0G6
Accessions	Q63HK5 AB040907 BAA95998 AI015687 AK291466 BAF84155 AK293267 BAG56797 AL136805 CAB66739 AM393571 CAL38448 BC127095 AAI27096 BC127096 AAI27097 BX648745 CAH56184 CN256026 NM_020856 NP_065907
Function	Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. {ECO:0000269|PubMed:19343227}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.
Tissue Specificity	Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease. {ECO:0000269|PubMed:18776146, ECO:0000269|PubMed:19343227}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TSHZ3 Antibody Blocking Peptide - LS-E11607 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSHZ3 Antibody Blocking Peptide - LS-E31243 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TSHZ3 Blocking Peptide - abx161232 from Abbexa Category Peptide Species Human, Mouse, Rat

TSHZ3 / ZNF537 (N-term) Control Peptide - AP55632CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TSHZ3 Peptide - 6759P from ProSci Category Peptide Species Human

TSHZ3 fusion protein - Ag18953 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TSHZ3 Blocking Peptide - CBP3731 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Teashirt homolog 3(TSHZ3) ,partial - CSB-YP734015HU CSB-EP734015HU CSB-BP734015HU CSB-MP734015HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TSHZ3 / ZNF537 - TP311499 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Teashirt homolog 3 (TSHZ3), partial, Recombinant Protein - MBS1304968 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZNF537 Recombinant Protein Antigen - NBP1-92629PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TSHZ3 Peptide, Human - M34GP16718H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more