| Gene Symbol |
TRIAP1
|
| Entrez Gene |
51499
|
| Alt Symbol |
HSPC132, MDM35, P53CSV, WF-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TP53 regulated inhibitor of apoptosis 1
|
| Other Description |
TP53-regulated inhibitor of apoptosis 1|mitochondrial distribution and morphology 35 homolog|p53-inducible cell-survival factor|protein 15E1.1
|
| Swissprots |
Q5RKS5 Q6LCA7 O43715 B2R4Z7
|
| Accessions |
EAW98192 O43715 AF161481 AAF29096 AK312006 BAG34944 BC002638 AAH02638 BC055313 AAH55313 CB141335 DQ893091 ABM84017 DQ896363 ABM87362 U75688 AAR00584 NM_016399 NP_057483
|
| Function |
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Mitochondrion. Mitochondrion intermembrane space.
|