Gene Symbol | TRIAP1 |
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Entrez Gene | 51499 |
Alt Symbol | HSPC132, MDM35, P53CSV, WF-1 |
Species | Human |
Gene Type | protein-coding |
Description | TP53 regulated inhibitor of apoptosis 1 |
Other Description | TP53-regulated inhibitor of apoptosis 1|mitochondrial distribution and morphology 35 homolog|p53-inducible cell-survival factor|protein 15E1.1 |
Swissprots | Q5RKS5 Q6LCA7 O43715 B2R4Z7 |
Accessions | EAW98192 O43715 AF161481 AAF29096 AK312006 BAG34944 BC002638 AAH02638 BC055313 AAH55313 CB141335 DQ893091 ABM84017 DQ896363 ABM87362 U75688 AAR00584 NM_016399 NP_057483 |
Function | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}. |
Subcellular Location | Cytoplasm, perinuclear region. Mitochondrion. Mitochondrion intermembrane space. |
p53CSV CRISPR/Cas9 KO Plasmid (h) - sc-405432 from Santa Cruz Biotechnology
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p53CSV HDR Plasmid (h) - sc-405432-HDR from Santa Cruz Biotechnology
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p53CSV Double Nickase Plasmid (h) - sc-405432-NIC from Santa Cruz Biotechnology
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p53CSV Double Nickase Plasmid (h2) - sc-405432-NIC-2 from Santa Cruz Biotechnology
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p53CSV CRISPR Activation Plasmid (h) - sc-405432-ACT from Santa Cruz Biotechnology
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p53CSV CRISPR Activation Plasmid (h2) - sc-405432-ACT-2 from Santa Cruz Biotechnology
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p53CSV Lentiviral Activation Particles (h) - sc-405432-LAC from Santa Cruz Biotechnology
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p53CSV Lentiviral Activation Particles (h2) - sc-405432-LAC-2 from Santa Cruz Biotechnology
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p53CSV siRNA (h) - sc-95976 from Santa Cruz Biotechnology
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p53CSV shRNA Plasmid (h) - sc-95976-SH from Santa Cruz Biotechnology
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p53CSV shRNA (h) Lentiviral Particles - sc-95976-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU044161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21949 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21949 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00030 from Sigma-Aldrich
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TRIAP1 siRNA (Human) - CRH9795 from Cohesion Biosciences
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TRIAP1 - MBS8231070 from MyBioSource
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shRNA set against Human TRIAP1 (NM_016399.2) - SHH434304 from Creative biogene
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shRNA set against Human TRIAP1(NM_016399.2) - SHL093018 from Creative biogene
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TRIAP1 shRNA Plasmid (Human) - CHH9795 from Cohesion Biosciences
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TRIAP1 miRNA 3'UTR clone - MiUTR1H-10709 from Creative biogene
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