Gene Symbol | PPP2R2D |
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Entrez Gene | 55844 |
Alt Symbol | MDS026 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 2, regulatory subunit B, delta |
Other Description | PP2A subunit B isoform B55-delta|PP2A subunit B isoform PR55-delta|PP2A subunit B isoform R2-delta|PP2A subunit B isoform delta|protein phosphatase 2, regulatory subunit B, delta isoform|serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform |
Swissprots | Q5SQJ2 Q9P1Y7 A8KAK0 Q66LE6 |
Accessions | EAW49145 EAW49146 EAW49147 Q66LE6 AB040974 BAA96065 AF220046 AAF67639 AI521071 AK000402 AK001483 BAG50921 AK293065 BAF85754 BC047379 AAH47379 BC058076 AAH58076 BC060885 BC072402 AAH72402 BQ023669 HQ447504 ADQ31990 XM_005277927 XP_005277984 XM_006717914 XP_006717977 XM_006717915 XP_006717978 XM_011539950 XP_011538252 XM_011539951 XP_011538253 XR_945786 NM_001003656 NM_001291310 NP_001278239 NM_018461 NP_060931 NR_033191 |
Function | B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Dopaminergic synapse, mRNA surveillance pathway, PI3K-Akt signaling pathway, Hepatitis C, Hippo signaling pathway |
PP2A-B55 (C-18) - sc-18330 from Santa Cruz Biotechnology
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Anti-PPP2R2D antibody [EPR13624] - ab181071 from Abcam
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Anti-PPP2R2D Antibody (aa380-429) - LS-C135373 from LifeSpan Bioscience
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PPP2R2D Antibody - NBP2-15081 from Novus Biologicals
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PPP2R2D Antibody - NBP2-33379 from Novus Biologicals
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Anti-PPP2R2D antibody produced in rabbit - HPA042770 from Sigma-Aldrich
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Anti-PPP2R2D antibody produced in rabbit - SAB2700104 from Sigma-Aldrich
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Ppp2r2d antibody - 70R-9373 from Fitzgerald
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Anti-PPP2R2D (aa 91-380) polyclonal antibody - DPABH-04667 from Creative Diagnostics
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Anti-PPP2R2D monoclonal antibody - DCABH-201299 from Creative Diagnostics
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PPP2R2D Polyclonal Antibody - PA5-30763 from Thermo Fisher Scientific
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PPP2R2D antibody [N2C3] - GTX116609 from GeneTex
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PPP2R2D Antibody - abx122635 from Abbexa
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PPP2R2D antibody - orb258681 from Biorbyt
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PPP2R2D Antibody,Biotin conjugated - CSB-PA727750LD01HU from Cusabio
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PPP2R2D Antibody,FITC conjugated - CSB-PA727750LC01HU from Cusabio
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PPP2R2D Antibody,HRP conjugated - CSB-PA727750LB01HU from Cusabio
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PPP2R2D Antibody - CSB-PA727750LA01HU from Cusabio
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PPP2R2D Polyclonal Antibody - CAC07651 from Biomatik
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Anti-PPP2R2D Antibody (aa380-429, Biotin) - LS-C461230 from LifeSpan Bioscience
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Anti-PPP2R2D Antibody (aa380-429, FITC) - LS-C461231 from LifeSpan Bioscience
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Anti-PPP2R2D Antibody (aa380-429, HRP) - LS-C461232 from LifeSpan Bioscience
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PPP2R2D, Polyclonal Antibody - MBS7044107 from MyBioSource
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PPP2R2D, Polyclonal Antibody - MBS7043885 from MyBioSource
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PPP2R2D, Polyclonal Antibody - MBS7043655 from MyBioSource
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