| Gene Symbol |
PPP2R2D
|
| Entrez Gene |
55844
|
| Alt Symbol |
MDS026
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 2, regulatory subunit B, delta
|
| Other Description |
PP2A subunit B isoform B55-delta|PP2A subunit B isoform PR55-delta|PP2A subunit B isoform R2-delta|PP2A subunit B isoform delta|protein phosphatase 2, regulatory subunit B, delta isoform|serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
|
| Swissprots |
Q5SQJ2 Q9P1Y7 A8KAK0 Q66LE6
|
| Accessions |
EAW49145 EAW49146 EAW49147 Q66LE6 AB040974 BAA96065 AF220046 AAF67639 AI521071 AK000402 AK001483 BAG50921 AK293065 BAF85754 BC047379 AAH47379 BC058076 AAH58076 BC060885 BC072402 AAH72402 BQ023669 HQ447504 ADQ31990 XM_005277927 XP_005277984 XM_006717914 XP_006717977 XM_006717915 XP_006717978 XM_011539950 XP_011538252 XM_011539951 XP_011538253 XR_945786 NM_001003656 NM_001291310 NP_001278239 NM_018461 NP_060931 NR_033191
|
| Function |
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Dopaminergic synapse, mRNA surveillance pathway, PI3K-Akt signaling pathway, Hepatitis C, Hippo signaling pathway
|
![Western Blot: PPP2R2D Overexpression Lysate (Adult Normal) [NBL1-14696] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PPP2R2D.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1186_PPP2R2D%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14696-img0002.jpg)