MAPKAPK3

Gene Symbol	MAPKAPK3
Entrez Gene	7867
Alt Symbol	3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 3
Other Description	MAP kinase-activated protein kinase 3|MAPK-activated protein kinase 3|MAPKAP kinase 3|chromosome 3p kinase
Swissprots	Q16644 B5BU67
Accessions	EAW65131 EAW65132 EAW65133 Q16644 AB451303 BAG70117 AB451434 BAG70248 AK290969 BAF83658 AK313565 BAG36339 BC001662 AAH01662 BC007591 AAH07591 BC010407 AAH10407 BC068497 BE301676 BM848086 DB450001 EU832627 ACE87718 EU832702 ACE87034 HQ447828 ADQ32312 U09578 AAD09136 U43784 AAC50428 XR_940501 NM_001243925 NP_001230854 NM_001243926 NP_001230855 NM_004635 NP_004626
Function	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38- alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcr
Subcellular Location	Nucleus {ECO:0000269|PubMed:15302577}. Cytoplasm {ECO:0000269|PubMed:15302577}. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Tissue Specificity	Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. {ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:8626550}.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat MAPKAPK3 ELISA Kit (Sandwich ELISA) - LS-F12002 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Human MAPKAPK3 ELISA Kit - abx054932 from Abbexa Category ELISA Kit

MAP kinase-activated protein kinase 3, MAPKAPK3, Human, ELISA Kit - E1632h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Mitogen Activated Protein Kinase Activated Protein Kinase 3, MAPKAPK3, Human, ELISA Kit - E-EL-H1138 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Mitogen Activated Protein Kinase Activated Protein Kinase 3, MAPKAPK3, Rabbit, ELISA Kit - E-EL-RB0234 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Mitogen Activated Protein Kinase Activated Protein Kinase 3, MAPKAPK3, Chicken, ELISA Kit - E-EL-Ch0743 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Mitogen Activated Protein Kinase Activated Protein Kinase 3, MAPKAPK3, Porcine, ELISA Kit - E-EL-P1706 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Mitogen Activated Protein Kinase Activated Protein Kinase 3, MAPKAPK3, Monkey, ELISA Kit - E-EL-MK0707 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

MAPKAPK3 (Human) IP-WB Antibody Pair - H00007867-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human MAPKAPK3 ELISA Kit - HM0235 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine MAPKAPK3 ELISA Kit - AM0235 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mitogen Activated Protein Kinase Activa Protein Kinase 3, ELISA Kit - MBS728512 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAPK3 Colorimetric Cell-Based ELISA - CB6037 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human MAPKAPK3(Mitogen Activated Protein Kinase Activated Protein Kinase 3) ELISA Kit - E-EL-H1138 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

MAPKAPK3, ELISA Kit - MBS2511151 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

MAPKAPK3, ELISA Kit - MBS2508620 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

MAPKAPK3, ELISA Kit - MBS2500245 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

MAPKAPK3, ELISA Kit - MBS2505395 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

MAPKAPK3, ELISA Kit - MBS2508243 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

Mitogen Activated Protein Kinase -Activa Protein Kinase 3, ELISA Kit - MBS750346 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase -Activa Protein Kinase 3, ELISA Kit - MBS021772 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase -Activa Protein Kinase 3, ELISA Kit - MBS750097 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase -Activa Protein Kinase 3, ELISA Kit - MBS027157 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase -Activa Protein Kinase 3, ELISA Kit - MBS014104 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase -Activa Protein Kinase 3, ELISA Kit - MBS722718 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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