MAPKAPK3

Gene Symbol	MAPKAPK3
Entrez Gene	7867
Alt Symbol	3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 3
Other Description	MAP kinase-activated protein kinase 3|MAPK-activated protein kinase 3|MAPKAP kinase 3|chromosome 3p kinase
Swissprots	Q16644 B5BU67
Accessions	EAW65131 EAW65132 EAW65133 Q16644 AB451303 BAG70117 AB451434 BAG70248 AK290969 BAF83658 AK313565 BAG36339 BC001662 AAH01662 BC007591 AAH07591 BC010407 AAH10407 BC068497 BE301676 BM848086 DB450001 EU832627 ACE87718 EU832702 ACE87034 HQ447828 ADQ32312 U09578 AAD09136 U43784 AAC50428 XR_940501 NM_001243925 NP_001230854 NM_001243926 NP_001230855 NM_004635 NP_004626
Function	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38- alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcr
Subcellular Location	Nucleus {ECO:0000269|PubMed:15302577}. Cytoplasm {ECO:0000269|PubMed:15302577}. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Tissue Specificity	Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. {ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:8626550}.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAPKAPK3 gene - orb91214 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-MAPKAPK3-cDNA-Clone - DC00769 from Abgent, a WuXi AppTec company Prices $515.70 Sizes 10 µg Species Human Accession BC001662

MAPKAPK3 - MBS1276027 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001662

Human MAPKAPK3/MK3 Gene ORF cDNA clone in cloning vector - HG10683-M from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10683-M-F from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10683-ACR from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10683-ANR from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10683-ANG from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid - HG10683-UT from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10683-ACG from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, N-His tag - HG10683-NH from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10683-NF from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10683-NM from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10683-CY from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10683-CF from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10683-CM from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10683-NY from Sino Biological Species Human

Human MAPKAPK3/MK3 Gene ORF cDNA clone expression plasmid, C-His tag - HG10683-CH from Sino Biological Species Human

Human MAPKAPK3 ORF Clone (BC001662) - CDCS409889 from Creative biogene Species Human Accession Q16644

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