MAPKAPK3

Gene Symbol	MAPKAPK3
Entrez Gene	7867
Alt Symbol	3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 3
Other Description	MAP kinase-activated protein kinase 3|MAPK-activated protein kinase 3|MAPKAP kinase 3|chromosome 3p kinase
Swissprots	Q16644 B5BU67
Accessions	EAW65131 EAW65132 EAW65133 Q16644 AB451303 BAG70117 AB451434 BAG70248 AK290969 BAF83658 AK313565 BAG36339 BC001662 AAH01662 BC007591 AAH07591 BC010407 AAH10407 BC068497 BE301676 BM848086 DB450001 EU832627 ACE87718 EU832702 ACE87034 HQ447828 ADQ32312 U09578 AAD09136 U43784 AAC50428 XR_940501 NM_001243925 NP_001230854 NM_001243926 NP_001230855 NM_004635 NP_004626
Function	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38- alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcr
Subcellular Location	Nucleus {ECO:0000269|PubMed:15302577}. Cytoplasm {ECO:0000269|PubMed:15302577}. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Tissue Specificity	Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. {ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:8626550}.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAPKAPK-3 Antibody - 3043 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

MAPKAPK-3 (D54E4) Rabbit mAb - 7421 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D54E4

3pK (B-2) - sc-376626 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

3pK (C-12) - sc-376743 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

3pK (C-4) - sc-365148 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

3pK (H-50) - sc-28782 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

3pK (N-19) - sc-1973 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-MAPKAP Kinase 3 antibody - ab64972 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPKAP Kinase 3 antibody - ab192305 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPKAP Kinase 3 antibody - ab58189 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAPKAP Kinase 3 antibody - ab58186 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAPKAP Kinase 3 antibody [EPR13969] - ab183040 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13969

Anti-MAPKAPK2/3 antibody - ab82543 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90, AP) - LS-C262639 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90, APC) - LS-C262640 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90, FITC) - LS-C262644 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90, Biotin) - LS-C262641 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90, Azide-free, HRP) - LS-C262646 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody - LS-C310937 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90, PE) - LS-C262647 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa62-90) - LS-C329816 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa301-350) - LS-C119080 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (aa1-50) - LS-C290944 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (C-Terminus) - LS-C135768 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MAPKAPK3 Antibody (C-Terminus) - LS-C135767 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Search more