MAPKAPK3

Gene Symbol	MAPKAPK3
Entrez Gene	7867
Alt Symbol	3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 3
Other Description	MAP kinase-activated protein kinase 3|MAPK-activated protein kinase 3|MAPKAP kinase 3|chromosome 3p kinase
Swissprots	Q16644 B5BU67
Accessions	EAW65131 EAW65132 EAW65133 Q16644 AB451303 BAG70117 AB451434 BAG70248 AK290969 BAF83658 AK313565 BAG36339 BC001662 AAH01662 BC007591 AAH07591 BC010407 AAH10407 BC068497 BE301676 BM848086 DB450001 EU832627 ACE87718 EU832702 ACE87034 HQ447828 ADQ32312 U09578 AAD09136 U43784 AAC50428 XR_940501 NM_001243925 NP_001230854 NM_001243926 NP_001230855 NM_004635 NP_004626
Function	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38- alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcr
Subcellular Location	Nucleus {ECO:0000269|PubMed:15302577}. Cytoplasm {ECO:0000269|PubMed:15302577}. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
Tissue Specificity	Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. {ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:8626550}.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MAPKAP Kinase 3 full length protein - ab60308 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human MAPKAP Kinase 3 full length protein - ab137158 from Abcam Category Protein Source E. coli Species Human

Human MAPKAP Kinase 3 full length protein - ab169914 from Abcam Category Protein Source E. coli Species Human

Human MAPKAP Kinase 3 full length protein - ab45155 from Abcam Category Protein Source E. coli Species Human

MAPKAPK3 Antibody Blocking Peptide - LS-E3127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK3 Antibody Blocking Peptide - LS-E22073 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK3 Antibody Blocking Peptide - LS-E22074 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAP Kinase 3 Recombinant Protein - H00007867-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MAPKAP Kinase 3 Partial Recombinant Protein - H00007867-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MAPKAP Kinase 3 Protein - NBP2-23246 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

MAPKAP Kinase 3 Recombinant Protein - P4238 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant MAPKAP Kinase 3 Protein - NBP1-99492 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

MAPKAPK3 (Active) recombinant protein - GTX65284 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human MAPKAPK3 protein - orb168778 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

MAPKAPK3 Blocking Peptide - 33R-7193 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAPKAPK3 Blocking Peptide - 33R-4327 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAPKAPK3 protein - 30R-2869 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

MAPKAPK3 protein (His tag) - 80R-2583 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

MAPKAP Kinase-3 (1-382, His-tag) - AR50629PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

MAPKAP Kinase-3 (1-382, His-tag) - AR50629PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

MAPKAP Kinase-3 - H00007867-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAPKAP Kinase-3 - H00007867-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAPKAP Kinase-3 - H00007867-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAPKAP Kinase-3 - H00007867-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAPKAP Kinase-3 - P4238 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

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