| Gene Symbol |
FAIM2
|
| Entrez Gene |
23017
|
| Alt Symbol |
LFG, LFG2, NGP35, NMP35, TMBIM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fas apoptotic inhibitory molecule 2
|
| Other Description |
neural membrane protein 35|protein lifeguard 2|transmembrane BAX inhibitor motif-containing protein 2
|
| Swissprots |
Q9BWQ8 Q9UJY9 B3KR08 Q9Y2F7 A8K1W6
|
| Accessions |
EAW58103 EAW58104 Q9BWQ8 AB023167 BAA76794 AF190461 AAF06327 AK090728 BAG52220 AK290031 BAF82720 AL707764 BC000051 AAH00051 BX647219 HQ448007 ADQ32488 XM_005268730 XP_005268787 NM_012306 NP_036438
|
| Function |
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:17635665}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269|PubMed:17635665}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:20336406}.
|