| Gene Symbol |
XRCC4
|
| Entrez Gene |
7518
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
X-ray repair complementing defective repair in Chinese hamster cells 4
|
| Other Description |
DNA repair protein XRCC4|X-ray repair cross-complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
|
| Swissprots |
Q13426 Q9UP94 A8K3X4 Q9BS72
|
| Accessions |
AAD47297 AAD47298 AAX14046 EAW95897 EAW95898 EAW95899 EAW95900 EAW95901 EAW95902 Q13426 AB017445 BAB20668 AK290739 BAF83428 BC005259 AAH05259 BC010655 AAH10655 BC016314 AAH16314 BT007216 AAP35880 DA067761 EU832713 ACE87045 U40622 AAC50339 XM_005248595 XP_005248652 XM_011543626 XP_011541928 XM_011543627 XP_011541929 XM_011543628 XP_011541930 XM_011543629 XP_011541931 NM_003401 NP_003392 NM_022406 NP_071801 NM_022550 NP_072044
|
| Function |
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:8548796}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:9259561}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8548796}.
|
| Top Pathways |
Non-homologous end-joining
|