XRCC4

Gene Symbol	XRCC4
Entrez Gene	7518
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 4
Other Description	DNA repair protein XRCC4|X-ray repair cross-complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
Swissprots	Q13426 Q9UP94 A8K3X4 Q9BS72
Accessions	AAD47297 AAD47298 AAX14046 EAW95897 EAW95898 EAW95899 EAW95900 EAW95901 EAW95902 Q13426 AB017445 BAB20668 AK290739 BAF83428 BC005259 AAH05259 BC010655 AAH10655 BC016314 AAH16314 BT007216 AAP35880 DA067761 EU832713 ACE87045 U40622 AAC50339 XM_005248595 XP_005248652 XM_011543626 XP_011541928 XM_011543627 XP_011541929 XM_011543628 XP_011541930 XM_011543629 XP_011541931 NM_003401 NP_003392 NM_022406 NP_071801 NM_022550 NP_072044
Function	Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:8548796}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:9259561}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8548796}.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

XRCC4 293T Cell Transient Overexpression Lysate(Denatured) - H00007518-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

XRCC4 293 Cell Lysate - 402551 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Hamster

XRCC4 Overexpression Lysate (Denatured) - H00007518-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

XRCC4 Overexpression Lysate (Native) - NBL1-17916 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

XRCC4 Overexpression Lysate (Native) - NBP2-08016 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

XRCC4 (h): 293T Lysate - sc-178146 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

XRCC4 Over-expression Lysate Product - GWB-18DF8A from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

XRCC4 Overexpression Lysate (Denatured) - H00007518-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human XRCC4 Knockdown Stable Cell Line - CSC-DC017596 from Creative biogene Category Cell Line Species Human

Human XRCC4 Knockout Cell Line-HeLa - CSC-RT1680 from Creative biogene Category Cell Line Species Human

XRCC4 KO Cell Lysate-HeLa - CLKO-1527 from Creative biogene Category Cell Lysate

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