XRCC4

Gene Symbol	XRCC4
Entrez Gene	7518
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 4
Other Description	DNA repair protein XRCC4|X-ray repair cross-complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
Swissprots	Q13426 Q9UP94 A8K3X4 Q9BS72
Accessions	AAD47297 AAD47298 AAX14046 EAW95897 EAW95898 EAW95899 EAW95900 EAW95901 EAW95902 Q13426 AB017445 BAB20668 AK290739 BAF83428 BC005259 AAH05259 BC010655 AAH10655 BC016314 AAH16314 BT007216 AAP35880 DA067761 EU832713 ACE87045 U40622 AAC50339 XM_005248595 XP_005248652 XM_011543626 XP_011541928 XM_011543627 XP_011541929 XM_011543628 XP_011541930 XM_011543629 XP_011541931 NM_003401 NP_003392 NM_022406 NP_071801 NM_022550 NP_072044
Function	Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:8548796}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:9259561}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8548796}.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

XRCC4 Antibody Blocking Peptide - LS-E6233 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC4 Antibody Blocking Peptide - LS-E12064 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human XRCC4 Protein - H00007518-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human XRCC4 Protein - H00007518-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

XRCC4-Antibody-Center-Blocking-Peptide - BP18904b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XRCC4 Blocking Peptide - 33R-5319 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XRCC4 Blocking Peptide - abx063431 from Abbexa Category Peptide Species Human, Mouse

XRCC4 - H00007518-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XRCC4 - H00007518-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

XRCC4 - H00007518-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XRCC4 - H00007518-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

XRCC4 fusion protein - Ag8606 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

XRCC4 fusion protein - Ag8807 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human XRCC4, His-tagged - XRCC4-30134TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human XRCC4, GST-tagged - XRCC4-3757H from Creative Biomart Category Protein Source E.coli Species Human

XRCC4 Blocking Peptide - CBP2237 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

XRCC4 (N291) Peptide - BS1496P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA repair protein XRCC4(XRCC4) - CSB-YP614413HU CSB-EP614413HU CSB-BP614413HU CSB-MP614413HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

XRCC4 Protein - abx164999 from Abbexa Category Protein Species Human, Rat

XRCC4 (transcript variant 3) - TP318029 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

XRCC4 (transcript variant 1) - TP312684 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

XRCC4 Protein - NBP1-89463PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

XRCC4 Peptide, Human - M34GP17596H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human XRCC4 protein - orb54353 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

XRCC4 Recombinant Protein Antigen - NBP2-58261PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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