XRCC4

Gene Symbol XRCC4
Entrez Gene 7518
Alt Symbol -
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 4
Other Description DNA repair protein XRCC4|X-ray repair cross-complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
Swissprots Q13426 Q9UP94 A8K3X4 Q9BS72
Accessions AAD47297 AAD47298 AAX14046 EAW95897 EAW95898 EAW95899 EAW95900 EAW95901 EAW95902 Q13426 AB017445 BAB20668 AK290739 BAF83428 BC005259 AAH05259 BC010655 AAH10655 BC016314 AAH16314 BT007216 AAP35880 DA067761 EU832713 ACE87045 U40622 AAC50339 XM_005248595 XP_005248652 XM_011543626 XP_011541928 XM_011543627 XP_011541929 XM_011543628 XP_011541930 XM_011543629 XP_011541931 NM_003401 NP_003392 NM_022406 NP_071801 NM_022550 NP_072044
Function Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:8548796}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:9259561}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8548796}.
Top Pathways Non-homologous end-joining

XRCC4 CRISPR/Cas9 KO Plasmid (h) - sc-417614 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 HDR Plasmid (h) - sc-417614-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 Double Nickase Plasmid (h) - sc-417614-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 Double Nickase Plasmid (h2) - sc-417614-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 CRISPR Activation Plasmid (h) - sc-417614-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 CRISPR Activation Plasmid (h2) - sc-417614-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 Lentiviral Activation Particles (h) - sc-417614-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 Lentiviral Activation Particles (h2) - sc-417614-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC4 siRNA (h) - sc-37405 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRCC4 shRNA Plasmid (h) - sc-37405-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRCC4 shRNA (h) Lentiviral Particles - sc-37405-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU091461 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1587 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1587 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04542 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04542

XRCC4 siRNA (Human) - CRH5139 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XRCC4 - MBS8216689 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human XRCC4 (NM_003401.3) - SHH448116 from Creative biogene

Category siRNA
Species Reactivities Human

Human XRCC4 siRNA - orb265641 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XRCC4 shRNA Plasmid (Human) - CHH5139 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

XRCC4 miRNA 3'UTR clone - MiUTR3H-02419 from Creative biogene

Species Reactivities Human

XRCC4 miRNA 3'UTR clone - MiUTR3H-02420 from Creative biogene

Species Reactivities Human

XRCC4 miRNA 3'UTR clone - MiUTR3H-02421 from Creative biogene

Species Reactivities Human
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