C1RL

Gene Symbol	C1RL
Entrez Gene	51279
Alt Symbol	C1RL1, C1RLP, C1r-LP, CLSPa
Species	Human
Gene Type	protein-coding
Description	complement component 1, r subcomponent-like
Other Description	C1r-like protein|C1r-like serine protease analog protein|complement C1r subcomponent-like protein|complement C1r-like proteinase
Swissprots	Q9NZP8 Q53GX9
Accessions	EAW88685 EAW88686 Q9NZP8 AF178985 AAF44349 AK024084 BAB14819 AK222802 BAD96522 AK314299 AW450562 BC062428 AAH62428 BC156780 AAI56781 DB113812 DR004214 HY062376 XM_005253386 XP_005253443 XM_005253387 XP_005253444 XM_006719084 XP_006719147 XM_006719085 XP_006719148 XM_011520688 XP_011518990 NM_001297640 NP_001284569 NM_001297642 NP_001284571 NM_001297643 NP_001284572 NM_016546 NP_057630
Function	Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15385675, ECO:0000269|PubMed:15527420}.
Subcellular Location	Secreted {ECO:0000269|PubMed:15358180}.
Tissue Specificity	Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV- 3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level). {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15527420}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

C1RL overexpression lysate - LY402565 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

C1RL 293 Cell Lysate - 402243 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Complement Component C1rLP Overexpression Lysate (Native) - NBL1-08350 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

C1RL Over-expression Lysate Product - GWB-E56292 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human C1RL Knockdown Stable Cell Line - CSC-DC001935 from Creative biogene Category Cell Line Species Human

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