C1RL

Gene Symbol C1RL
Entrez Gene 51279
Alt Symbol C1RL1, C1RLP, C1r-LP, CLSPa
Species Human
Gene Type protein-coding
Description complement component 1, r subcomponent-like
Other Description C1r-like protein|C1r-like serine protease analog protein|complement C1r subcomponent-like protein|complement C1r-like proteinase
Swissprots Q9NZP8 Q53GX9
Accessions EAW88685 EAW88686 Q9NZP8 AF178985 AAF44349 AK024084 BAB14819 AK222802 BAD96522 AK314299 AW450562 BC062428 AAH62428 BC156780 AAI56781 DB113812 DR004214 HY062376 XM_005253386 XP_005253443 XM_005253387 XP_005253444 XM_006719084 XP_006719147 XM_006719085 XP_006719148 XM_011520688 XP_011518990 NM_001297640 NP_001284569 NM_001297642 NP_001284571 NM_001297643 NP_001284572 NM_016546 NP_057630
Function Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15385675, ECO:0000269|PubMed:15527420}.
Subcellular Location Secreted {ECO:0000269|PubMed:15358180}.
Tissue Specificity Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV- 3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level). {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15527420}.

C1rL CRISPR/Cas9 KO Plasmid (h) - sc-412167 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL HDR Plasmid (h) - sc-412167-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL Double Nickase Plasmid (h) - sc-412167-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL Double Nickase Plasmid (h2) - sc-412167-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL CRISPR Activation Plasmid (h) - sc-412167-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL CRISPR Activation Plasmid (h2) - sc-412167-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL Lentiviral Activation Particles (h) - sc-412167-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL Lentiviral Activation Particles (h2) - sc-412167-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C1rL siRNA (h) - sc-96010 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C1rL shRNA Plasmid (h) - sc-96010-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C1rL shRNA (h) Lentiviral Particles - sc-96010-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU043001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4701 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4701 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10480 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10480

C1RL siRNA (Human) - CRH9657 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C1RL - MBS8240539 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C1RL (NM_016546.2) - SHH250889 from Creative biogene

Category siRNA
Species Reactivities Human

C1RL shRNA Plasmid (Human) - CHH9657 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C1RL miRNA 3'UTR clone - MiUTR3H-10345 from Creative biogene

Species Reactivities Human
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