| Gene Symbol |
TMPRSS11D
|
| Entrez Gene |
9407
|
| Alt Symbol |
HAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transmembrane protease, serine 11D
|
| Other Description |
airway trypsin like protease|airway trypsin-like protease|transmembrane protease serine 11D
|
| Swissprots |
O60235 Q08AF6
|
| Accessions |
AAY40996 EAX05559 O60235 AB002134 BAA28691 AK094054 AK290289 BAF82978 AK296853 BAG59419 AL603214 BC033295 BC125195 AAI25196 BC125196 AAI25197 XM_005265710 XP_005265767 NM_004262 NP_004253
|
| Function |
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. {ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:24227843}.
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.
|
| Tissue Specificity |
Located in the cells of the submucosal serous glands of the bronchi and trachea.
|