IFIH1

Gene Symbol	IFIH1
Entrez Gene	64135
Alt Symbol	AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1
Species	Human
Gene Type	protein-coding
Description	interferon induced with helicase C domain 1
Other Description	CADM-140 autoantigen|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RIG-I-like receptor 2|RNA helicase-DEAD box protein 116|clinically amyopathic dermatomyositis autoantigen 140 kDa|helicard|helicase with 2 CARD domains|interferon-induced helicase C domain-containing protein 1|melanoma differentiation associated protein-5|melanoma differentiation-associated protein 5|murabutide down-regulated protein
Swissprots	Q9H3G6 Q2NKL6 Q6DC96 Q86X56 Q96MX8 Q9BYX4
Accessions	AAX93137 AAY24206 EAX11352 Q9BYX4 AF095844 AAG34368 AK056293 BAB71141 AK292941 BAF85630 AK314611 AY017378 AAG54076 BC007966 BC046208 AAH46208 BC078180 AAH78180 BC111750 AAI11751 BQ772836 BU902097 XM_011511628 XP_011509930 XM_011511629 XP_011509931 NM_022168 NP_071451
Function	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:14645903}. Nucleus {ECO:0000305}. Note=May be found in the nucleus, during apoptosis.
Tissue Specificity	Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:12015121, ECO:0000269|PubMed:14645903}.
Top Pathways	RIG-I-like receptor signaling pathway, Measles, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IFIH1 / MDA5 ELISA Kit (Sandwich ELISA) - LS-F9792 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Human IFIH1 ELISA Kit - abx151904 from Abbexa Category ELISA Kit Sensitivity 0.115 ng/ml Range 0.313 ng/ml - 20 ng/ml

Interferon-induced helicase C domain-containing protein 1 (IFIH1), Human, ELISA Kit - CSB-EL011017HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.03 pg/ml Range 28.12 pg/ml-1800 pg/ml

Interferon-induced helicase C domain-containing protein 1, IFIH1, Human, ELISA Kit - E2803h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

IFIH1 (Human) IP-WB Antibody Pair - H00064135-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody (CADM-140 Ab) , ELISA Kit - MBS707228 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CADM-140 Ab antibody is typically less than 0.156 U/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.624U/ml-40 U/ml.

interferon induced with helicase C domain 1, ELISA Kit - MBS924321 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7 pg/ml. Range 28 pg/ml -1800 pg/ml.

ELISA Kit for Interferon Induced Helicase C Domain Containing Protein 1 (IFIH1) - SEL608Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody（CADM-14 - CSB-EQ028021HU from Cusabio Sensitivity Request Information Range Request Information

Human Interferon-induced helicase C domain-containing protein 1(IFIH1) ELISA kit - CSB-EL011017HU from Cusabio Category ELISA Kit Sensitivity 7 pg/ml Range 28 pg/ml-1800 pg/ml

ELISA Kit for Interferon Induced Helicase C Domain Containing Protein 1 (IFIH1) - SEL608Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse IFIH1 / MDA5 ELISA Kit (Custom ELISA) - LS-F19794 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Interferon Induced Helicase C Domain Containing Protein 1 (IFIH1), ELISA Kit - MBS2022859 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.115ng/mL. Range 0.313-20ng/mL

Human IFIH1 / MDA5 ELISA Kit (Sandwich ELISA) - LS-F13243 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 0.313-20 ng/ml

Human Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody(CADM-140 Ab) ELISA Kit - EKC33150 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity Request Information Range Request Information

IFIH1 - EKH4478 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

IFIH1 ELISA Kit (Human) : 96 Wells (OKEH01672) - OKEH01672 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 39 pg/mL Range 78 - 5000 pg/mL

Human IFIH1 ELISA Kit - E020304 from Biobool Category ELISA Kit Sensitivity Typically less than 0.115ng/mL.

Human Interferon-induced helicase C domain-containing protein 1 ELISA Kit - EK4547 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.078ng/mL Range 0.156-10 ng/mL

anti-IFIH1 / MDA5 antibody - ARG55413 from Arigo Biolaboratories Category ELISA Kit

anti-MDA5 / IFIH1 antibody - ARG63323 from Arigo Biolaboratories Category ELISA Kit

Interferon-induced helicase C domain-containing protein 1, ELISA Kit - MBS2883877 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <39 pg/mL Range 78-5000 pg/mL

Interferon-induced helicase C domain-containing protein 1, ELISA Kit - MBS9428373 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 39pg/mL Range 78-5000 pg/mL

Interferon-induced helicase C domain-containing protein 1, ELISA Kit - MBS763560 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

Human IFIH1 / MDA5 ELISA Kit (Sandwich ELISA) - LS-F33771 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 0.313-20 ng/ml

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